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Chest:慢性呼吸道症状与心血管疾病和全因死亡率之间的关联

2021-11-22 MedSci原创 MedSci原创

青年时期的慢性呼吸道症状与心血管疾病风险增加和中年人全因死亡率的增加相关,而与已知的心血管危险因素、吸烟和肺功能无关。

呼吸系统疾病和血管疾病(CVD)经常并存;然而,关于青年期慢性呼吸道症状与迟发性心血管疾病之间关系的证据十分有限。

近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员旨在明确青年时期的慢性呼吸道症状是否与晚年CVD和全因死亡率相关?

该研究共有4621名年龄在18-30岁之间的年轻人冠状动脉风险发展(CARDIA)队列研究的参与者被纳入在内。在连续两次检查中通过呼吸道症状问卷确定了慢性呼吸道症状。在30年的随访中,研究人员对CVD事件和全因死亡率进行了判定。多变量Cox比例风险模型用于探索慢性呼吸道症状与CVD事件和全因死亡率之间的关联。

在中位随访30.9年期间,共发生了284起CVD事件(6.15%)和378起死亡(8.18%)。对人口统计学、心血管危险因素、吸烟和肺功能进行多变量调整后,任何呼吸系统症状的心血管事件风险比(95%CI)为1.51(1.18-1.93),咳嗽或咳痰为1.57(1.18-2.09),喘息为1.31(1.01-1.68),气短为1.73(1.25-2.41),胸部疾病为1.32(1.01-1.71)。在全因死亡率中也观察到类似的结果。相比于0种呼吸道症状,3-4种呼吸道症状患者的心血管疾病风险比(95%CI)为1.97(1.34-2.91),全因死亡率为1.75(1.23-2.47)。在各种敏感性分析中观察到类似的结果。

由此可见,青年时期的慢性呼吸道症状与心血管疾病风险增加和中年人全因死亡率的增加相关,而与已知的心血管危险因素、吸烟和肺功能无关。识别青年时期的慢性呼吸道症状可能有助于提供有关未来心血管健康的预后信息。

原始出处:

Weijing Feng.et al.Association of chronic respiratory symptoms with incident cardiovascular disease and all-cause mortality: findings from the Coronary Artery Risk Development in Young Adults Study.chest.2021.https://journal.chestnet.org/article/S0012-3692(21)04255-0/fulltext

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    2022-08-31 waj970409

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    2022-07-22 Smile2680
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    2021-11-24 zhmscau
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    2021-11-22 ms5000000126067505

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    2021-11-22 ms5000000518166734

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