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Eur Respir J:哮喘和哮喘药物对COVID-19患者预后的影响

2020-09-30 MedSci原创 MedSci原创

哮喘是COVID-19患者不良预后的重要因素。然而,一般而言,哮喘、哮喘药物的使用和哮喘严重程度并不是COVID-19患者疗效差的独立因素。

2019新型冠状病毒病(COVID-19)已在世界范围内迅速传播。但是,哮喘、哮喘药物和哮喘严重程度对COVID-19患者临床结局的影响尚未确定。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,该研究纳入了7590例通过严重急性呼吸综合征-冠状病毒2 RNA-聚合酶链反应试验(截至2020年5月15日)确认为COVID-19患者,并且使用了健康保险审查与评估服务提供的医疗链接数据。研究人员使用诊断代码和哮喘药物使用史来定义有无哮喘和哮喘的严重程度。

7590名COVID-19患者中,有218名(2.9%)患者伴有哮喘。哮喘患者与COVID-19相关的总医疗费用显著高于其他患者。伴有哮喘的COVID-19患者死亡率(7.8%)显著高于其他患者(2.8%;p<0.001)。但是,调整后哮喘并不是COVID-19患者临床结局的独立危险因素。哮喘药物的使用和哮喘的严重程度也没有影响COVID-19患者的临床结局。然而,口服短效β2-激动剂(SABA)是总医疗费用负担增加的独立因素。在单因素和多因素分析中,与第1期哮喘患者相比,第5期哮喘患者的住院时间显著延长。

由此可见,哮喘是COVID-19患者不良预后的重要因素。然而,一般而言,哮喘、哮喘药物的使用和哮喘严重程度并不是COVID-19患者疗效差的独立因素。

原始出处:

Yong Jun Choi,et al.Effect of Asthma and Asthma Medication on the Prognosis of Patients with COVID-19.Eur Respir J.2020.https://erj.ersjournals.com/content/early/recent

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    2021-05-25 huangdf
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    2020-10-12 ms3000001612065059

    学习

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=2035647, encodeId=0d3d203564e16, content=<a href='/topic/show?id=5fa83995011' target=_blank style='color:#2F92EE;'>#哮喘药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39950, encryptionId=5fa83995011, topicName=哮喘药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Tue May 25 21:02:49 CST 2021, time=2021-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1692157, encodeId=f472169215e75, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Wed Dec 16 11:02:49 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891456, encodeId=a2dc8914568d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73f75422892, createdName=ms3000001612065059, createdTime=Mon Oct 12 13:21:11 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297482, encodeId=d996129e48266, content=<a href='/topic/show?id=c0385134ab' target=_blank style='color:#2F92EE;'>#COVID-19患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5134, encryptionId=c0385134ab, topicName=COVID-19患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Fri Oct 02 02:02:49 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889470, encodeId=5e9c8894e022, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd0c5416012, createdName=ms8000002124067161, createdTime=Wed Sep 30 18:41:30 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889384, encodeId=420d88938415, content=好 , beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201110/2d55d24dc5fd419d994b7b920c79731b/d3c8bdca983c4af1b90220a8192e353a.jpg, createdBy=e14e5296465, createdName=飞翔的乌龟, createdTime=Wed Sep 30 12:30:10 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889383, encodeId=cb898893831b, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200930/8d1311080a4348b5b3642f92c2e7fe7a/f6b8d9ee0eb9419fa95228731e537f27.jpg, createdBy=3a8f5422894, createdName=ms9000001275799741, createdTime=Wed Sep 30 12:21:28 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889379, encodeId=74ca8893e9f5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q3auHgzwzM6tia9pyZiaPziaeLHadUZP17uiav8DTro6peFy5lvuO5EjYrG4ButKWVynGX1CUFFBbXhib9bjE77pkHw/132, createdBy=41785253089, createdName=医路前行4231, createdTime=Wed Sep 30 11:45:16 CST 2020, time=2020-09-30, status=1, ipAttribution=)]
    2020-09-30 ms8000002124067161

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2035647, encodeId=0d3d203564e16, content=<a href='/topic/show?id=5fa83995011' target=_blank style='color:#2F92EE;'>#哮喘药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39950, encryptionId=5fa83995011, topicName=哮喘药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Tue May 25 21:02:49 CST 2021, time=2021-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1692157, encodeId=f472169215e75, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Wed Dec 16 11:02:49 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891456, encodeId=a2dc8914568d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73f75422892, createdName=ms3000001612065059, createdTime=Mon Oct 12 13:21:11 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297482, encodeId=d996129e48266, content=<a href='/topic/show?id=c0385134ab' target=_blank style='color:#2F92EE;'>#COVID-19患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5134, encryptionId=c0385134ab, topicName=COVID-19患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Fri Oct 02 02:02:49 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889470, encodeId=5e9c8894e022, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd0c5416012, createdName=ms8000002124067161, createdTime=Wed Sep 30 18:41:30 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889384, encodeId=420d88938415, content=好 , beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201110/2d55d24dc5fd419d994b7b920c79731b/d3c8bdca983c4af1b90220a8192e353a.jpg, createdBy=e14e5296465, createdName=飞翔的乌龟, createdTime=Wed Sep 30 12:30:10 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889383, encodeId=cb898893831b, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200930/8d1311080a4348b5b3642f92c2e7fe7a/f6b8d9ee0eb9419fa95228731e537f27.jpg, createdBy=3a8f5422894, createdName=ms9000001275799741, createdTime=Wed Sep 30 12:21:28 CST 2020, time=2020-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889379, encodeId=74ca8893e9f5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q3auHgzwzM6tia9pyZiaPziaeLHadUZP17uiav8DTro6peFy5lvuO5EjYrG4ButKWVynGX1CUFFBbXhib9bjE77pkHw/132, createdBy=41785253089, createdName=医路前行4231, createdTime=Wed Sep 30 11:45:16 CST 2020, time=2020-09-30, status=1, ipAttribution=)]
    2020-09-30 飞翔的乌龟

    0

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    2020-09-30 ms9000001275799741

    好文章

    0

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    2020-09-30 医路前行4231

    学习了

    0

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Eur Respir J:肥胖和正常体重哮喘患者哮喘药物分析

尽管FEV1较低且FEV1/FVC%较低,肥胖的哮喘患者使用的哮喘药物种类和ICS剂量均高于正常体重的哮喘患者。需要更好地了解导致药物使用增加的因素,以改善哮喘亚组的预后。

JAMA:维生素D3补充不能降低哮喘患儿恶化风险

研究认为,对于持续哮喘且维生素D水平较低的患儿,补充维生素D3不能降低患者哮喘恶化风险

ERS 2020:高剂量Enerzair Breezhaler可进一步减轻哮喘发作

一项最新研究显示,与中等剂量相比,高剂量Enerzair Breezhaler(醋酸茚达特罗/溴化格隆溴铵/糠酸莫米松)可显著降低哮喘发作。

BMJ:与儿童哮喘相关的空气及家庭因素研究

PM2.5是诱发儿童哮喘和持续性喘息的重要风险因素,其他相关的危险因素包括父母哮喘、父母社会经济地位和孕期吸烟

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