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JAHA:小左心室与经导管主动脉瓣置换术后临床结局的关系

2021-03-21 MedSci原创 MedSci原创

由简单的超声心动图参数确定的小LV与TAVR患者较差的临床预后相关,而与LF左心室肥厚无关。左心室大小可能有助于评估TAVR后的临床结局。

在接受经导管主动脉瓣置换术(TAVR)的患者中,左心室(LV)较小的患者出现预后不良的风险可能会增加,因为小LV与低流量(LF)的左室肥大有关。然而,小LV对接受TAVR的患者的影响尚未明确。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员使用日本多中心注册表中的数据评估了2013年10月至2017年5月期间接受TAVR的2584例患者。根据美国超声心动图学会指南,小LV定义为男性左室舒张末期尺寸<42.0 mm,女性<37.8 mm。研究人员使用多变量Cox回归分析和倾向评分匹配,比较有无左室肥厚患者的2年临床结局。研究人员通过LF左心室肥大进行亚组分析。

在接受TAVR的2584例患者中,466例(18.0%)患有小LV。与没有小LV的患者相比,小LV的患者体型较小且合并症较少,并且更可能伴有LF状态。

小LV与较高的2年全因(20.8% vs. 14.3%;调整后的风险比[HR]为1.58 [95%CI为1.20–2.09]; P=0.0013)和心血管(8.8% vs. 5.5%;调整后的HR为1.93 [95%CI为1.25-2.98];P=0.0028)死亡率相关。倾向得分匹配分析显示一致的结果。在亚组分析中,LF左心室肥厚与小LV无关。

由此可见,由简单的超声心动图参数确定的小LV与TAVR患者较差的临床预后相关,而与LF左心室肥厚无关。左心室大小可能有助于评估TAVR后的临床结局。

原始出处:

Tetsuya Saito.et al.Small Left Ventricle and Clinical Outcomes After Transcatheter Aortic Valve Replacement.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019543

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    2021-04-02 yxch48
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encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Fri Apr 02 10:51:23 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843251, encodeId=5240184325144, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Sun Apr 18 19:51:23 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268469, encodeId=e4da1268469a0, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, 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time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415731, encodeId=46ee1415e31a3, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Tue Mar 23 03:51:23 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510329, encodeId=58b51510329b8, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, 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    2021-03-23 zhaohui6731
  5. 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time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415731, encodeId=46ee1415e31a3, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Tue Mar 23 03:51:23 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510329, encodeId=58b51510329b8, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, 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  6. 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  7. 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  8. 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  9. 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time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415731, encodeId=46ee1415e31a3, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Tue Mar 23 03:51:23 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510329, encodeId=58b51510329b8, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, 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    2021-03-23 lsj631
  10. 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