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Heart:高效他汀可降低急性心梗患者死亡率

2014-02-25 高晓方 译 医学论坛网

英国一项研究表明,与辛伐他汀单药治疗相比,转为高效他汀类治疗的患者死亡率显著降低。而在依折麦布组中未观察到患者在死亡率方面的获益。论文2月19日在线发表于《心脏》(Heart)。此项回顾性纵向研究共纳入9597例首次急性心肌梗死30天后仍存活者;受试者既往未接受过他汀类或依折麦布治疗,并且在急性心梗30天内启动他汀类治疗。依据随访情况将患者分为辛伐他汀单药治疗组、高效他汀类药物治疗组(起始为辛伐他

英国一项研究表明,与辛伐他汀单药治疗相比,转为高效他汀类治疗的患者死亡率显著降低。而在依折麦布组中未观察到患者在死亡率方面的获益。论文2月19日在线发表于《心脏》(Heart)。

此项回顾性纵向研究共纳入9597例首次急性心肌梗死30天后仍存活者;受试者既往未接受过他汀类或依折麦布治疗,并且在急性心梗30天内启动他汀类治疗。依据随访情况将患者分为辛伐他汀单药治疗组、高效他汀类药物治疗组(起始为辛伐他汀,后转为阿托伐他汀或瑞舒伐他汀)以及依折麦布/他汀类药物联合治疗组。

结果显示,辛伐他汀组、高效他汀类药物治疗组和依折麦布/他汀类药物联合治疗组分别纳入6990、1883和724例患者。在平均随访3.2年期间,共出现1134例(12%)死亡。在多变量比例风险模型中,高效他汀类药物治疗组和依折麦布组的校正危险比分别为0.72和0.96。在纳入协变量的倾向评分分析中可得出相似结果。

原始出处:

Pauriah M1, Elder DH, Ogston S, Noman AY, Majeed A, Wyatt JC, Choy AM, Macdonald TM, Struthers AD, Lang CC.High-potency statin and ezetimibe use and mortality in survivors of an acute myocardial infarction: a population-based study.Heart. 2014 Feb 19. doi: 10.1136/heartjnl-2013-304678.

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    2014-06-29 lidage

    强化他汀治疗又有了新证据

    0

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    2014-02-27 zhaojie88
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