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Nat Commun:糖尿病治愈有望了,研究发现良性肿瘤中蕴藏着对抗糖尿病的基因秘诀

2017-10-04 佚名 Medicalxpress

西奈山医学院的研究人员指出,罕见良性肿瘤,胰岛瘤包含着胰岛素再生的复杂接线图,这有可能成为糖尿病药物开发的关键。研究发表于《通信》杂志中。

西奈山医学院的研究人员指出,罕见良性肿瘤,胰岛瘤包含着胰岛素再生的复杂接线图,这有可能成为糖尿病药物开发的关键。研究发表于《通信》杂志中。

这项标题洞察β细胞再生通过集成分子景观在人类糖尿病胰岛瘤,发表在在线学习在本质上通信。

在研究中,西奈山医学院研究小组收集来自38名参与者的胰岛瘤胰腺肿瘤分泌过多的胰岛素以及他们的基因组学和表达模式分析。研究人员表示:“这是我们第一次通过实际接线图来分析β细胞复制基因组。”

据调查,大约有3000万美国人患有糖尿病,还有近50万到8000万人患有前驱糖尿病。患糖尿病时,患者没有足够的胰腺β细胞,或当这些β细胞胰岛素分泌过少的时候,也无法将血糖保持在正常范围内,糖尿病会导致主要的并发症包括心脏病,中风,肾衰竭,失明和截肢。

研究人员们一致认为产生胰岛素的β细胞损失是导致1型糖尿病的根源,近年来,研究人员得出结论,缺乏β细胞功能对2型糖尿病也同样重要。因此,开发可以增加健康的β细胞数量的药物是糖尿病研究的主要任务。

通过全新的完整图谱研究,研究人员找到了治疗糖尿病的新方向,相信在不久的将来糖尿病将不再是难题。

原始出处:
Huan Wang, Aaron Bender, Peng Wang,et al.Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.Nature Communications, 03 October 2017doi:10.1038/s41467-017-00992-9

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    2018-03-08 liuli5079
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    2018-06-17 liye789132251
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    2017-10-04 天涯183

    非常好的文章.学习了

    0

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    2017-10-04 1e0e5697m83(暂无匿称)

    henhao

    0

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    2017-10-04 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2017-10-04 lovetcm

    很难

    0

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