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CELL METAB:调节血糖的神奇微生物-益生素(post-biotics)

2017-04-21 浮生若梦 来宝网

【益生素(post-biotics)可帮助肥胖者避免糖尿病】你可能听说过益生元和益生菌,现在你将更多听到的是益生素(post-biotics)。注:post-biotics还未有正式译名,暂叫益生素,也有的称其为活生素。麦克马斯特大学的研究人员开始确认益生素(post-biotics),一种细菌副产物,如何降低血糖,并调节胰岛素更好的工作。生物化学和生物医学助理教授,Jonathan Schert


你可能听说过益生元和益生菌,现在你将更多听到的是益生素(post-biotics)。

注:post-biotics还未有正式译名,暂叫益生素,也有的称其为活生素。

麦克马斯特大学的研究人员开始确认益生素(post-biotics),一种细菌副产物,如何降低血糖,并调节胰岛素更好的工作。

生物化学和生物医学助理教授,Jonathan Schertzer,其论文发表于《细胞代谢》上,这样解释到:

“我们知道肠道细菌,通常叫做微生物,会发出炎症信号来促使胰岛素的工作,从而降低血糖

通常细菌被认为是仅能引起各种问题,例如引发炎症和高血糖。但这仅仅是事实的一半。我们发现细菌的一个特定组分实际上能够降低血糖,并促使胰岛素在肥胖阶段更好的工作。

了解细菌的不同组分如何控制葡萄糖能够建立新的治疗方法,以避免益生元和益生菌带来的问题。我们发现了“益生素“,它能够在肥胖时降低血糖。”

这项工作有非常重要的意义,超过一半的加拿大人都超重或者肥胖,导致了高水平的血中胰岛素和血糖,这些糖尿病前期特征都将最终导致2型糖尿病

Schertzer说:“我们现在还不完全了解触发血糖升高的机制,这非常重要,因为只有部分肥胖的人发展成为糖尿病,血糖受我们的基因、吃的食物和肠道微生物的影响。”

他的研究团队正致力于开发新的微生物基础的药物,用来降低血糖和预防糖尿病前期转化为2型糖尿病。同时,他们已经在小鼠的临床试验中成功应用药物治疗骨肉瘤,骨癌的一种。

原始出处:

Cavallari JF, Fullerton MD, Duggan BM, et al. Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4. CELL METAB. 2017 Apr 20.

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    2017-07-22 一闲
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    2018-03-07 维他命
  5. [GetPortalCommentsPageByObjectIdResponse(id=1824752, encodeId=97901824e5269, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Sep 16 05:22:00 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896028, encodeId=7b6e1896028d3, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Jul 22 01:22:00 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869913, encodeId=4bfc186991394, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Sep 12 09:22:00 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960172, encodeId=bf6119601e2b3, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Mar 07 19:22:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887616, encodeId=0e09188e616c1, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Oct 12 00:22:00 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917452, encodeId=640d191e452ee, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Dec 30 08:22:00 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189517, encodeId=456318951e75, content=调节血糖的神奇物种, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Apr 22 00:57:55 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
    2017-10-12 guojianrong
  6. [GetPortalCommentsPageByObjectIdResponse(id=1824752, encodeId=97901824e5269, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Sep 16 05:22:00 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896028, encodeId=7b6e1896028d3, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Jul 22 01:22:00 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869913, encodeId=4bfc186991394, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Sep 12 09:22:00 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960172, encodeId=bf6119601e2b3, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Mar 07 19:22:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887616, encodeId=0e09188e616c1, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Oct 12 00:22:00 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917452, encodeId=640d191e452ee, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Dec 30 08:22:00 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189517, encodeId=456318951e75, content=调节血糖的神奇物种, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Apr 22 00:57:55 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
    2017-12-30 sunylz
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    2017-04-22 雾夜芭蕾

    调节血糖的神奇物种

    0

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