Baidu
map

尿微量白蛋白:早期肾损伤的“信号兵”

2019-06-12 冯少婷 检验医学网

王阿姨患有糖尿病,复查时医生需要检测她的尿微量白蛋白,同时需要王阿姨留取24小时尿,王阿姨说:“我之前测过尿常规,蛋白也没有加号,没有留尿啊,怎么这次不一样?”其实,和王阿姨一样,一些糖尿病或者肾脏疾病患者面对这样的检查,也有同样的困惑:到底什么是尿微量白蛋白,和尿常规检测的尿蛋白有什么区别呢?


作者:天津医科大学肿瘤医院检验科   冯少婷

王阿姨患有糖尿病,复查时医生需要检测她的尿微量白蛋白,同时需要王阿姨留取24小时尿,王阿姨说:“我之前测过尿常规,蛋白也没有加号,没有留尿啊,怎么这次不一样?”其实,和王阿姨一样,一些糖尿病或者肾脏疾病患者面对这样的检查,也有同样的困惑:到底什么是尿微量白蛋白,和尿常规检测的尿蛋白有什么区别呢?

1982年Viberti等发现糖尿病患者尿中总蛋白在正常范围,而尿白蛋白排泄增加的现象,首先提出了尿微量白蛋白(mAlb)的概念。微量白蛋白(mAlb):指尿中Alb排出量在30-300mg/24h范围内,即已超出正常上限(30mg/24h),但尚未达临床蛋白尿水平的中间阶段。

微量白蛋白测定反映早期肾病、肾损伤情况。病理性增高见于糖尿病肾病、高血压、妊娠子痫前期。在早期尿微量白蛋白阶段是肾病发生的早期信号和预兆,此时肾脏损害处在尚可逆转的时期,如能及时治疗,可以终止或逆转肾病的发展进程。

糖尿病肾病是糖尿病最常见的慢性并发症之一.糖尿病肾病早期无明显症状和体征,尿蛋白常规检查也多为阴性,这给早期诊断造成困难。因此,检测尿微量白蛋白对于早期发现糖尿病肾小球微血管病变具有十分重要的意义。同时,为了避免患者运动或其他生理因素产生尿蛋白,可以收集患者24小时尿总量,检测其中所有蛋白质含量,进而做出早期诊断,开展早期治疗。

相对尿微量白蛋白的定量检查,常说的检测尿常规是对尿蛋白定性检查,结果以“+”表示,“+”越多,表示蛋白流失的越多。方法简单,易操作,主要适用于门诊或健康查体。

因此,尿微量白蛋白这个“信号兵”,不仅能早期发现肾损伤,还能定量检测尿中的蛋白,对于早期发现肾脏损害无疑是较好的检测指标。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1304650, encodeId=29fc130465023, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397769, encodeId=b801139e7690c, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614129, encodeId=4d331614129d4, content=<a href='/topic/show?id=3cb54e420f6' target=_blank style='color:#2F92EE;'>#尿微量白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47420, encryptionId=3cb54e420f6, topicName=尿微量白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15f319497178, createdName=ms306040998833292, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367712, encodeId=c8b136e71268, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Fri Jun 14 05:30:01 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367672, encodeId=727736e672b8, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Jun 13 06:44:03 CST 2019, time=2019-06-13, status=1, ipAttribution=)]
    2019-06-14 珙桐
  2. [GetPortalCommentsPageByObjectIdResponse(id=1304650, encodeId=29fc130465023, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397769, encodeId=b801139e7690c, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614129, encodeId=4d331614129d4, content=<a href='/topic/show?id=3cb54e420f6' target=_blank style='color:#2F92EE;'>#尿微量白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47420, encryptionId=3cb54e420f6, topicName=尿微量白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15f319497178, createdName=ms306040998833292, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367712, encodeId=c8b136e71268, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Fri Jun 14 05:30:01 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367672, encodeId=727736e672b8, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Jun 13 06:44:03 CST 2019, time=2019-06-13, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1304650, encodeId=29fc130465023, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397769, encodeId=b801139e7690c, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614129, encodeId=4d331614129d4, content=<a href='/topic/show?id=3cb54e420f6' target=_blank style='color:#2F92EE;'>#尿微量白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47420, encryptionId=3cb54e420f6, topicName=尿微量白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15f319497178, createdName=ms306040998833292, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367712, encodeId=c8b136e71268, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Fri Jun 14 05:30:01 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367672, encodeId=727736e672b8, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Jun 13 06:44:03 CST 2019, time=2019-06-13, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1304650, encodeId=29fc130465023, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397769, encodeId=b801139e7690c, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614129, encodeId=4d331614129d4, content=<a href='/topic/show?id=3cb54e420f6' target=_blank style='color:#2F92EE;'>#尿微量白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47420, encryptionId=3cb54e420f6, topicName=尿微量白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15f319497178, createdName=ms306040998833292, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367712, encodeId=c8b136e71268, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Fri Jun 14 05:30:01 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367672, encodeId=727736e672b8, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Jun 13 06:44:03 CST 2019, time=2019-06-13, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1304650, encodeId=29fc130465023, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397769, encodeId=b801139e7690c, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614129, encodeId=4d331614129d4, content=<a href='/topic/show?id=3cb54e420f6' target=_blank style='color:#2F92EE;'>#尿微量白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47420, encryptionId=3cb54e420f6, topicName=尿微量白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15f319497178, createdName=ms306040998833292, createdTime=Fri Jun 14 14:12:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367712, encodeId=c8b136e71268, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Fri Jun 14 05:30:01 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367672, encodeId=727736e672b8, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Jun 13 06:44:03 CST 2019, time=2019-06-13, status=1, ipAttribution=)]
    2019-06-13 深海的鱼

    学习学习学习

    0

相关资讯

微量白蛋白——检测肾损伤 量微作用大

李大爷拿着自己的尿液检验报告单找大夫解惑:“为什么明明已经有了一个尿蛋白了,下面又有一个微量白蛋白呀?它们有什么区别?”不得不说大爷火眼金睛,这微小的差别可有大学问。尿蛋白大家都知道是尿的常规项目了,而尿微量白蛋白,近年来逐渐发展起来的一个更灵敏更具有早期诊断意义的一个新名词,下面我们就来了解了解它:

Sci Rep:上尿路移行细胞癌中,白蛋白和碱性磷酸酶比例的预后意义

最近,有研究人员为了评估上尿路移行细胞癌(UTUC)患者中,治疗前白蛋白和碱性磷酸酶比(AAPR)的预后影响,对2003年和2016年之间的692名患者的数据进行了回顾性的分析。研究人员通过接受者操作特性曲线分析定义了AAPR的阈值为0.58,并利用Kaplan-Meier方法对总生存(OS)、癌症特异性生存(CSS)和无复发生存(RFS)进行了评估。另外,还利用单变量和多变量Cox回归模型来鉴定

CLIN CHEM:基于白蛋白校正钙研究,在三级医院环境中的钙营养状况的错误分类

临床实验室测量总钙并校正白蛋白浓度以预测钙营养状况。研究人员将总钙和校正钙(Adj-Ca)与离子钙(Ca 2+)进行了比较,以正确分配钙营养状况。根据错误分类的频率确定限制低蛋白血症患者的Adj-Ca报告的效果。 研究人员连续收集24个月的实验室测量结果。由改良的Payne公式计算Adj-Ca。在停止报告白蛋白<3.0g / dL的患者的Adj-Ca后,收集了6个月的进一步前

白蛋白应该是低血容量患者液体复苏的**胶体吗?

血流动力学管理是危重症和急诊医学的一项主要治疗挑战。在患者从入院到出院整个康复过程中起着关键作用。在恢复血流动力学稳定期间,复苏是液体管理的主要指标之一,经常是救命治疗,需以正确的剂量、速率,并选择正确的液体种类尽可能快的给予。不幸的是,这些核心的液体治疗在科学文献中并未得到一致性和可靠证据的支持。对正确的患者应用正确的液体的管理仍是一个争议根源的准则。然而,在2013年EMA和FDA发布了限制H

白蛋白超过总蛋白,真凶竟是……

患者,男,68岁,因“贫血,血小板减少就诊”,患者在门诊检验血常规显示重度贫血(HGB:54g/L),血小板减少(PLT:71×109/L),淋巴细胞比例异常增高(LYM%:90.2%),淋巴细胞如此之高,涂片镜检可见大量淋巴细胞,患者血常规检测结果如图。

J Hepatol: 采用midodrine和白蛋白治疗肝硬化患者,血管收缩系统活性轻微下降,但不能阻碍肝硬化并发症和改善患者生存

等待肝移植的肝硬化患者,在采用 midodrine和白蛋白治疗后,内源性血管收缩系统活性有轻微下降,但并不能阻碍肝硬化并发症和改善患者生存。

Baidu
map
Baidu
map
Baidu
map