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Gastroenterology:肝纤维化程度在非酒精性脂肪肝患者预后中的价值

2020-02-04 MedSci MedSci原创

肝纤维化程度是决定非酒精性脂肪肝患者预后的重要影响因素

肝纤维化是影响非酒精性脂肪肝(NAFLD)患者预后的重要因素。近日研究人员进行了系统综述及荟萃分析,以量化纤维化阶段在NAFLD患者和非酒精性脂肪性肝炎(NA H)患者预后的价值。

研究收集了2018年8月前的相关资料,考察NAFLD或NASH患者按纤维化阶段分层(活检确定)的死亡率(全因和肝脏相关)和发病率(肝硬化、肝癌和所有肝脏相关事件)数据。

总计13个研究,4428名NAFLD患者纳入本次研究,包含2875名NASH患者。相对于无纤维化人群,纤维化患者(4期患者)的全因死亡风险(RR)为3.42、肝病相关死亡风险为11.13、肝移植风险为5.42、肝相关事件风险为12.78,且相关风险不受年龄及性别的影响。

研究发现,肝纤维化程度是决定非酒精性脂肪肝患者预后的重要影响因素。

原始出处:


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01:20:00 CST 2020, time=2020-02-06, status=1, ipAttribution=)]
  5. 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01:20:00 CST 2020, time=2020-02-06, status=1, ipAttribution=)]
    2020-04-19 许安
  6. 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  7. 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