Age Ageing：老年人有“心”病易伤“脑”
2012-12-07 程蓓 编译 Age Ageing
英国一项基于人群的队列研究显示，老年人心血管风险的增加可能与其认知功能的加速衰退相关。论文11月25日在线发表于《年龄与衰老》（Age Ageing）杂志。 研究纳入英国老龄化纵向研究中的老年人。临床转归指标包括总体认知、记忆和执行功能。结果显示，在随访4年时，与弗雷明汉卒中危险评分（FSR）较低的四分位者相比，FSR最高四分位者的总体认知、记忆和执行功能得分较低。研究对象的收
英国一项基于人群的队列研究显示，老年人心血管风险的增加可能与其认知功能的加速衰退相关。论文11月25日在线发表于《年龄与衰老》（Age Ageing）杂志。
研究纳入英国老龄化纵向研究中的老年人。临床转归指标包括总体认知、记忆和执行功能。结果显示，在随访4年时，与弗雷明汉卒中危险评分（FSR）较低的四分位者相比，FSR最高四分位者的总体认知、记忆和执行功能得分较低。研究对象的收缩压≥160 mmHg与随访8年时其总体认知和特殊记忆得分较低相关。吸烟与上述3种认知功能转归较差持续相关。
Objectives
the objective of the present study was to explore the association between cardiovascular risk and cognitive decline in adults aged 50 and over.
Methods
participants were older adults who participated in the English Longitudinal Study of Ageing. Outcome measures included standardised z-scores for global cognition, memory and executive functioning. Associations between cardiovascular risk factors and 10-year Framingham risk scores with cognitive outcomes at 4-year and 8-year follow-ups were estimated.
Results
the mean age of participants (n = 8,780) at 2004–05 survey was 66.93 and 55% were females. Participants in the highest quartile of Framingham stroke risk score (FSR) had lower global cognition (b = 0.73,CI: 1.37, 0.10), memory (b = 0.56, CI: 0.99, 0.12) and executive (b = 0.37, CI: 0.74, 0.01) scores at 4-year follow-up compared with those in the lower quartile. Systolic blood pressure ≥160 mmHg at 1998–2001 survey was associated with lower global cognitive (b = 1.26, CI: 2.52, 0.01) and specific memory (b = 1.16, CI: 1.94, 0.37) scores at 8-year follow-up. Smoking was consistently associated with lower performance on all three cognitive outcomes.
Conclusion
elevated cardiovascular risk may be associated with accelerated decline in cognitive functioning in the elderly. Future intervention studies may be better focused on overall risk rather than individual risk factor levels.
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本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
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