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J Natl Cancer Inst：肺癌驱动基因新发现

2012-08-10 奎妮 中国医学论坛报

EPHA3肺癌
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　　EPHA3是酪氨酸激酶受体家族成员之一，是肺癌中常见的突变基因。英国学者研究证实：至少有两种肿瘤相关的EPHA3突变可抑制EPHA3蛋白的正常功能；野生型EPHA3的过表达可抑制下游Akt信号转导通路，诱导细胞凋亡，抑制肿瘤细胞生成；EPHA3基因突变后影响对Akt途径的抑制，从而促进细胞生长；在肺癌组织中，EPHA3基因的拷贝数和（或）表达水平降低。该研究7月24日在线发表于《国立癌症研究所

　　EPHA3是酪氨酸激酶受体家族成员之一，是肺癌中常见的突变基因。英国学者研究证实：至少有两种肿瘤相关的EPHA3突变可抑制EPHA3蛋白的正常功能；野生型EPHA3的过表达可抑制下游Akt信号转导通路，诱导细胞凋亡，抑制肿瘤细胞生成；EPHA3基因突变后影响对Akt途径的抑制，从而促进细胞生长；在肺癌组织中，EPHA3基因的拷贝数和（或）表达水平降低。该研究7月24日在线发表于《国立癌症研究所杂志》（J Natl Cancer Inst）。



    

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1661471, encodeId=28c916614e128, content=<a href='/topic/show?id=34a110150800' target=_blank style='color:#2F92EE;'>#驱动基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101508, encryptionId=34a110150800, topicName=驱动基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b94625296381, createdName=751943081_32627957, createdTime=Wed Sep 19 15:30:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879348, encodeId=f29f18e934847, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 19 19:30:00 CST 2012, time=2012-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950161, encodeId=35d219501618e, content=<a href='/topic/show?id=f3b329482a' target=_blank style='color:#2F92EE;'>#ATL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2948, encryptionId=f3b329482a, topicName=ATL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Tue Feb 19 00:30:00 CST 2013, time=2013-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977479, encodeId=687919e747907, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Mon Nov 26 15:30:00 CST 2012, time=2012-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921080, encodeId=264e1921080b4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Thu Aug 23 00:30:00 CST 2012, time=2012-08-23, status=1, ipAttribution=)]
    2012-09-19 751943081_32627957

    #驱动基因#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1661471, encodeId=28c916614e128, content=<a href='/topic/show?id=34a110150800' target=_blank style='color:#2F92EE;'>#驱动基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101508, encryptionId=34a110150800, topicName=驱动基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b94625296381, createdName=751943081_32627957, createdTime=Wed Sep 19 15:30:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879348, encodeId=f29f18e934847, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 19 19:30:00 CST 2012, time=2012-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950161, encodeId=35d219501618e, content=<a href='/topic/show?id=f3b329482a' target=_blank style='color:#2F92EE;'>#ATL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2948, encryptionId=f3b329482a, topicName=ATL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Tue Feb 19 00:30:00 CST 2013, time=2013-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977479, encodeId=687919e747907, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Mon Nov 26 15:30:00 CST 2012, time=2012-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921080, encodeId=264e1921080b4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Thu Aug 23 00:30:00 CST 2012, time=2012-08-23, status=1, ipAttribution=)]
    2012-11-19 liye789132251

    #Nat#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1661471, encodeId=28c916614e128, content=<a href='/topic/show?id=34a110150800' target=_blank style='color:#2F92EE;'>#驱动基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101508, encryptionId=34a110150800, topicName=驱动基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b94625296381, createdName=751943081_32627957, createdTime=Wed Sep 19 15:30:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879348, encodeId=f29f18e934847, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 19 19:30:00 CST 2012, time=2012-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950161, encodeId=35d219501618e, content=<a href='/topic/show?id=f3b329482a' target=_blank style='color:#2F92EE;'>#ATL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2948, encryptionId=f3b329482a, topicName=ATL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Tue Feb 19 00:30:00 CST 2013, time=2013-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977479, encodeId=687919e747907, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Mon Nov 26 15:30:00 CST 2012, time=2012-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921080, encodeId=264e1921080b4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Thu Aug 23 00:30:00 CST 2012, time=2012-08-23, status=1, ipAttribution=)]
    2013-02-19 qidongfanjian

    #ATL#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1661471, encodeId=28c916614e128, content=<a href='/topic/show?id=34a110150800' target=_blank style='color:#2F92EE;'>#驱动基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101508, encryptionId=34a110150800, topicName=驱动基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b94625296381, createdName=751943081_32627957, createdTime=Wed Sep 19 15:30:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879348, encodeId=f29f18e934847, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 19 19:30:00 CST 2012, time=2012-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950161, encodeId=35d219501618e, content=<a href='/topic/show?id=f3b329482a' target=_blank style='color:#2F92EE;'>#ATL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2948, encryptionId=f3b329482a, topicName=ATL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Tue Feb 19 00:30:00 CST 2013, time=2013-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977479, encodeId=687919e747907, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Mon Nov 26 15:30:00 CST 2012, time=2012-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921080, encodeId=264e1921080b4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Thu Aug 23 00:30:00 CST 2012, time=2012-08-23, status=1, ipAttribution=)]
    2012-11-26 drj2003

    #NST#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1661471, encodeId=28c916614e128, content=<a href='/topic/show?id=34a110150800' target=_blank style='color:#2F92EE;'>#驱动基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101508, encryptionId=34a110150800, topicName=驱动基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b94625296381, createdName=751943081_32627957, createdTime=Wed Sep 19 15:30:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879348, encodeId=f29f18e934847, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 19 19:30:00 CST 2012, time=2012-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950161, encodeId=35d219501618e, content=<a href='/topic/show?id=f3b329482a' target=_blank style='color:#2F92EE;'>#ATL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2948, encryptionId=f3b329482a, topicName=ATL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Tue Feb 19 00:30:00 CST 2013, time=2013-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977479, encodeId=687919e747907, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Mon Nov 26 15:30:00 CST 2012, time=2012-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921080, encodeId=264e1921080b4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Thu Aug 23 00:30:00 CST 2012, time=2012-08-23, status=1, ipAttribution=)]
    2012-08-23 vera_1203

    #新发现#

    0

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