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J Thromb Haemost:初始肿瘤分期对静脉血栓栓塞的发病率有何影响?

2017-06-06 xing.T MedSci原创

由此可见,在诊断时分期更晚的癌症患者发生VTE的风险较高,但这种相关性的强度随着癌症类型的变化有很大的差别。

癌症分期对不同类型癌症患者的静脉血栓栓塞(VTE)发生率的影响还没有在大型基于人群的队列研究中被研究。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员通过一项大型基于人群的队列研究,根据癌症的发展,旨在客观评价VTE的发病率差异。研究人员考虑了癌症类型和诊断时分期。

斯堪的纳维亚血栓形成和癌症队列中144952名参与者自1993年随访至2012年,其包含了癌症类型、分期和客观证实的VTE诊断数据。研究人员分析了10种实体肿瘤的分期特异性VTE发生率和根据分期计算了VTE的累积发病率差异(IRD)。

在整个随访期间,共发生了335次VTE,其中293次VTE发生在5年内。远处转移肿瘤患者相比于局限性肿瘤患者VTE的IRD根据癌症的类型有所变化。在胰腺癌患者中研究人员观察到了最高的IRD(IRD为187×10-3人次每年(p-y);95%可信区间为6.7-380.8),而在前列腺癌患者中观察到的最低的IRD(IRD为3.7×10-3 p-y;95%可信区间为7-15.2)。区域转移与局部疾病相比也表现出了根据肿瘤类型较大的差异,其中,子宫癌有最大的IRD(IRD为37.6×10-3 p-y;95%可信区间为23.7-99),而在乳腺癌和前列腺癌的IRD接近零。

由此可见,在诊断时分期更晚的癌症患者发生VTE的风险较高,但这种相关性的强度随着癌症类型的变化有很大的差别。

原始出处:


I. L. Gade,et al. The Impact of Initial Cancer Stage on the Incidence of Venous Thromboembolism: The Scandinavian Thrombosis and Cancer (STAC) Cohort.Journal of Thrombosis and Haemostasis.2017. http://onlinelibrary.wiley.com/doi/10.1111/jth.13752/full

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    2017-12-28 一叶知秋
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85172002258, createdName=珍珍superwoman, createdTime=Sun Jun 11 16:43:47 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208829, encodeId=479620882996, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85172002258, createdName=珍珍superwoman, createdTime=Sat Jun 10 07:01:04 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208317, encodeId=8f2b20831e8f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jun 07 08:29:12 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2018-04-09 fusion
  5. [GetPortalCommentsPageByObjectIdResponse(id=1823344, encodeId=6fa41823344ce, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Jul 27 09:52:00 CST 2017, time=2017-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740295, encodeId=24e71e40295f5, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85172002258, createdName=珍珍superwoman, createdTime=Sun Jun 11 16:43:47 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208829, encodeId=479620882996, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85172002258, createdName=珍珍superwoman, createdTime=Sat Jun 10 07:01:04 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208317, encodeId=8f2b20831e8f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jun 07 08:29:12 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2018-03-30 xue8602
  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jun 07 08:29:12 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-11 珍珍superwoman

    学习了

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jun 07 08:29:12 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-10 珍珍superwoman

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1823344, encodeId=6fa41823344ce, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Jul 27 09:52:00 CST 2017, time=2017-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740295, encodeId=24e71e40295f5, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, 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encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Mon Apr 09 19:52:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955292, encodeId=feb0195529262, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Fri Mar 30 12:52:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209452, encodeId=4d1d20945251, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85172002258, createdName=珍珍superwoman, createdTime=Sun Jun 11 16:43:47 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208829, encodeId=479620882996, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85172002258, createdName=珍珍superwoman, createdTime=Sat Jun 10 07:01:04 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208317, encodeId=8f2b20831e8f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Thu Jun 08 23:09:35 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207620, encodeId=e0b620e6202d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Jun 07 08:37:08 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207613, encodeId=3e2320e613a4, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jun 07 08:29:12 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-08 䖝二

    学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1823344, encodeId=6fa41823344ce, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Jul 27 09:52:00 CST 2017, time=2017-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740295, encodeId=24e71e40295f5, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, createdName=12498c32m79暂无昵称, createdTime=Fri Mar 16 04:52:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008263, encodeId=9b0a2008263b2, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Dec 28 16:52:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697473, encodeId=7654169e47304, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Mon Apr 09 19:52:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955292, encodeId=feb0195529262, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Fri Mar 30 12:52:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209452, encodeId=4d1d20945251, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85172002258, createdName=珍珍superwoman, createdTime=Sun Jun 11 16:43:47 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208829, encodeId=479620882996, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85172002258, createdName=珍珍superwoman, createdTime=Sat Jun 10 07:01:04 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208317, encodeId=8f2b20831e8f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Thu Jun 08 23:09:35 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207620, encodeId=e0b620e6202d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Jun 07 08:37:08 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207613, encodeId=3e2320e613a4, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jun 07 08:29:12 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-07 lou.minghong

    学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1823344, encodeId=6fa41823344ce, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Jul 27 09:52:00 CST 2017, time=2017-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740295, encodeId=24e71e40295f5, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jun 07 08:29:12 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-07 楠博One

    学习谢谢分享

    0

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