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Diabetes:低血糖恢复后心血管危险因素恶化

2012-08-29 高晓方 医学论坛网

低血糖恢复1型糖尿病炎症内皮功能心血管危险
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　　欧洲学者的一项研究表明，1型糖尿病患者的低血糖恢复可能在内皮功能障碍、氧化应激和炎症及广泛认知的心血管危险因素方面发挥重要作用。论文于2012年8月13日在线发表于《糖尿病》（Diabetes）杂志。 　　此项研究以正常和1型糖尿病个体为受试者。通过2小时诱导低血糖后恢复2小时正常血糖或高血糖继之维持6小时正常血糖实现低血糖恢复。在同时输注维生素C的条件下重复低血糖后高血糖。 　　结果显示

　　欧洲学者的一项研究表明，1型糖尿病患者的低血糖恢复可能在内皮功能障碍、氧化应激和炎症及广泛认知的心血管危险因素方面发挥重要作用。论文于2012年8月13日在线发表于《糖尿病》（Diabetes）杂志。

　　此项研究以正常和1型糖尿病个体为受试者。通过2小时诱导低血糖后恢复2小时正常血糖或高血糖继之维持6小时正常血糖实现低血糖恢复。在同时输注维生素C的条件下重复低血糖后高血糖。

　　结果显示，正常血糖恢复伴随有内皮功能障碍、氧化应激和炎症的显著改善，但低血糖后高血糖阶段上述指标则恶化，并且该效应可持续至附加6小时正常血糖之后。同时输注维生素C可部分对抗上述不良影响，提示此阶段可能存在缺血再灌注样效应。

　　链接：Antonio Ceriello1,2⇓,Anna Novials1,2,Emilio Ortega1,2,Lucia La Sala1,Gemma Pujadas1,Roberto Testa3,Anna Rita Bonfigli3, Katherine Esposito4 and Dario Giugliano4.Evidence That Hyperglycemia After Recovery From Hypoglycemia Worsens Endothelial Function and Increases Oxidative Stress and Inflammation in Healthy Control Subjects and Subjects With Type 1 Diabetes.Diabetes



    

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    2013-01-11 ms5439512287675881

    #BET#

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    2013-06-09 木头人513

    #Diabetes#

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    2013-03-31 xinmeili

    #血管危险因素#

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    2012-09-29 ms9608593228839890

    #DIA#

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    2012-08-31 yuhaisheng_ibp_32061711

    #心血管危险因素#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1759185, encodeId=40b01e59185ac, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Jan 11 02:28:00 CST 2013, time=2013-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1900994, encodeId=8ec919009946f, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Jun 09 02:28:00 CST 2013, time=2013-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948884, encodeId=46d7194888482, content=<a href='/topic/show?id=1e4789584b0' target=_blank style='color:#2F92EE;'>#血管危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89584, encryptionId=1e4789584b0, topicName=血管危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sun Mar 31 04:28:00 CST 2013, time=2013-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636555, encodeId=203b163655501, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 29 09:28:00 CST 2012, time=2012-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331452, encodeId=4c4c133145299, content=<a href='/topic/show?id=afab51e831d' target=_blank style='color:#2F92EE;'>#心血管危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51783, encryptionId=afab51e831d, topicName=心血管危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Fri Aug 31 01:28:00 CST 2012, time=2012-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629733, encodeId=ac771629e33ec, content=<a href='/topic/show?id=28c351e80dc' target=_blank style='color:#2F92EE;'>#心血管危险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51780, encryptionId=28c351e80dc, topicName=心血管危险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3e0221357465, createdName=lingaifan, createdTime=Fri Aug 31 01:28:00 CST 2012, time=2012-08-31, status=1, ipAttribution=)]
    2012-08-31 lingaifan

    #心血管危险#

    0

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