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GUT:HCV患者实现SVR后肝外疾病风险显著降低

2018-05-02 zhangfan MedSci原创

研究认为,对于HCV感染人群,抗病毒治疗后实现SVR可显著减少肝外疾病风险

HCV的肝外表现是导致许多慢性感染患者发病和死亡的主要原因。现阶段全新的无干扰素全口服抗病毒方案为HCV的治疗带来了突变性进展。

近日研究人员开展系统综述和荟萃研究,对HCV感染者持续病毒学应答(SVR)对肝外疾病的影响进行了考察。

总计48个相关研究参与本次荟萃分析。相比于未实现SVR人群,实现SVR可降低肝外死亡率(OR 0.44,95% CI 0.28-0.67)。SVR患者其冷球蛋白血症血管炎(OR 20.76,6.73-64.05)以及恶性B淋巴细胞增生性疾病(OR 6.49,2.02-20.85)完全缓解率较高。实现SVR可降低随访过程中胰岛素抵抗风险(OR 0.42,0.33-0.53),并降低后续糖尿病发病率(OR 0.34,0.21-0.56)。

研究认为,对于HCV感染人群,抗病毒治疗后实现SVR可显著减少肝外疾病风险。

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    2018-05-04 ymljack
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    2018-05-04 w363522450
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    2018-05-02 忠诚向上

    好好学习天天向上

    0

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