本周糖尿病重磅：强生降糖药INVOKAMET获FDA批准一线治疗2型糖尿病，英国NICE推荐3种SGLT-2降糖药

2016-05-28 佚名生物谷Bioon.com

英国医疗成本监管机构NICE（英国国家卫生与临床优化研究所）近日发布指南，推荐3种糖尿病单药疗法用于英格兰和威尔士国家卫生服务（NHS）系统，用于2型糖尿病患者的治疗，包括强生的Invokana（canagliflozin，卡格列净）、阿斯利康的Forxiga（dapagliflozin，达格列净）、勃林格殷格翰的Jardiance（empagliflozin，恩格列净）。目前，在全球范围内，

英国医疗成本监管机构NICE（英国国家卫生与临床优化研究所）近日发布指南，推荐3种糖尿病单药疗法用于英格兰和威尔士国家卫生服务（NHS）系统，用于2型糖尿病患者的治疗，包括强生的Invokana（canagliflozin，卡格列净）、阿斯利康的Forxiga（dapagliflozin，达格列净）、勃林格殷格翰的Jardiance（empagliflozin，恩格列净）。

目前，在全球范围内，二甲双胍（metformin）是临床上治疗2型糖尿病应用最广泛的一线口服降糖药，常处方用于2型糖尿病的早期治疗。但有些患者在服用二甲双胍后会经历一些副作用，比如恶心或腹泻，有些患者出于其他原因（如不耐受或禁忌症）可能不适合二甲双胍治疗。对于那些也不适合服用磺脲类降糖药或吡格列酮治疗的2型糖尿病患者，此次推荐的3种降糖药可考虑作为一种治疗选择。

NICE表示，与DPP-4抑制剂类降糖药相比，此次推荐的3种降糖药更具成本效益。据估计，在英国，有多达350万糖尿病患者，其中大约90%的成人患者确诊为2型糖尿病。NICE预计，大约有3.1万例2型糖尿病患者有资格接受此次推荐的3种降糖药。

本周糖尿病重磅消息：FDA批准强生降糖药INVOKAMET用于2型糖尿病一线治疗

Invokana（canagliflozin，卡格列净）、Forxiga（dapagliflozin，达格列净）、Jardiance（empagliflozin，恩格列净）均属于钠-葡萄糖协同转运蛋白-2（sodium glucose co-transporter 2，SGLT-2）抑制剂类降糖药，在美国，这3者分别于2013年11月、2014年1月、2014年8月获FDA批准上市，分别是美国市场中的第1、2、3个SGLT-2抑制剂。SGLT-2抑制剂是一类新型降糖药，主要通过抑制表达于肾脏的SGLT2，减少肾脏的葡萄糖重吸收，增加尿液中葡萄糖的排泄，从而达到降低血糖水平的效果，而且该降糖效果不依赖于β细胞功能和胰岛素抵抗。

本周，强生的糖尿病复方药VOKANAMET（canagliflozin/metformin，卡格列净/二甲双胍）喜获FDA批准，用于2型糖尿病的一线治疗。VOKANAMET最初于2014年8月获批，是美国市场中首个由SGLT2抑制剂和二甲双胍组成的复方药物，该药是由固定剂量canagliflozin和速释二甲双胍组成的复方单片，在单一片剂中结合了2种机制互补的降糖药，可同时提供canagliflozin及二甲双胍的临床属性。

Jardiance（恩格列净）：全球首个被证实可降低2型糖尿病心血管风险的降糖药

另外值得一提的是，Jardiance（恩格列净）是全球首个在心血管终点试验中被证实可降低心血管风险的降糖药。具有里程碑意义的EMPA-REG OUTCOME临床研究显示，在伴有高风险心血管（CV）事件的2型糖尿病成人患者中，与安慰剂+标准护理相比，Jardiance+标准护理显著降低了患者的心血管风险。今年1月，FDA已受理Jardiance（恩格列净）补充新药申请，如果获批，Jardiance将成为市面上首个能够减少2型糖尿病患者心血管疾病风险的降血糖药物。

今年4月底，糖尿病巨头诺和诺德开发的一款新的长效胰高血糖素样肽-1（GLP-1）受体激动剂semaglutide（索马鲁肽）在III期临床也被证实能够显著降低2型糖尿病患者重大心血管事件风险，该药属于胰高血糖素样肽-1（GLP-1）受体激动剂类降糖药，这是另一类新兴的降糖药。

原始出处：

NICE backs three medicines for type 2 diabetes

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2016-08-05 bugit

#FDA批准#

63 0
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2016-09-24 一闲

#MET#

60 0
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2016-06-25 tulenzi

#SGLT#

97 0
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2017-05-10 fmq_28614553

#SGLT-2#

56 0
[GetPortalCommentsPageByObjectIdResponse(id=1839432, encodeId=0d1c183943243, content=<a href='/topic/show?id=341ae311ea' target=_blank style='color:#2F92EE;'>#FDA批准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7311, encryptionId=341ae311ea, topicName=FDA批准)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Fri Aug 05 19:05:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895903, encodeId=94a118959038a, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Sep 24 11:05:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793779, encodeId=e7641e9377971, content=<a href='/topic/show?id=5a3f1621e7d' target=_blank style='color:#2F92EE;'>#SGLT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16217, encryptionId=5a3f1621e7d, topicName=SGLT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Sat Jun 25 21:05:00 CST 2016, time=2016-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081967, encodeId=b7b1208196e42, content=<a href='/topic/show?id=acf116218e6' target=_blank style='color:#2F92EE;'>#SGLT-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16218, encryptionId=acf116218e6, topicName=SGLT-2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a3a2500014, createdName=fmq_28614553, createdTime=Wed May 10 00:05:00 CST 2017, time=2017-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270833, encodeId=519712e0833f1, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271642, encodeId=a3ad12e16428e, content=<a href='/topic/show?id=2c6c501e578' target=_blank style='color:#2F92EE;'>#强生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50175, encryptionId=2c6c501e578, topicName=强生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288928, encodeId=a6c91288928f0, content=<a href='/topic/show?id=077112e9237' target=_blank style='color:#2F92EE;'>#NICE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12792, encryptionId=077112e9237, topicName=NICE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521609, encodeId=3edc1521609b6, content=<a href='/topic/show?id=18bb8e08622' target=_blank style='color:#2F92EE;'>#英国NICE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87086, encryptionId=18bb8e08622, topicName=英国NICE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ce711379167, createdName=lvygwyt2785, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548841, encodeId=1f9115488411d, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=)]
2016-05-30 minlingfeng

#降糖药#

75 0
[GetPortalCommentsPageByObjectIdResponse(id=1839432, encodeId=0d1c183943243, content=<a href='/topic/show?id=341ae311ea' target=_blank style='color:#2F92EE;'>#FDA批准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7311, encryptionId=341ae311ea, topicName=FDA批准)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Fri Aug 05 19:05:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895903, encodeId=94a118959038a, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Sep 24 11:05:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793779, encodeId=e7641e9377971, content=<a href='/topic/show?id=5a3f1621e7d' target=_blank style='color:#2F92EE;'>#SGLT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16217, encryptionId=5a3f1621e7d, topicName=SGLT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Sat Jun 25 21:05:00 CST 2016, time=2016-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081967, encodeId=b7b1208196e42, content=<a href='/topic/show?id=acf116218e6' target=_blank style='color:#2F92EE;'>#SGLT-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16218, encryptionId=acf116218e6, topicName=SGLT-2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a3a2500014, createdName=fmq_28614553, createdTime=Wed May 10 00:05:00 CST 2017, time=2017-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270833, encodeId=519712e0833f1, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271642, encodeId=a3ad12e16428e, content=<a href='/topic/show?id=2c6c501e578' target=_blank style='color:#2F92EE;'>#强生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50175, encryptionId=2c6c501e578, topicName=强生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288928, encodeId=a6c91288928f0, content=<a href='/topic/show?id=077112e9237' target=_blank style='color:#2F92EE;'>#NICE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12792, encryptionId=077112e9237, topicName=NICE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521609, encodeId=3edc1521609b6, content=<a href='/topic/show?id=18bb8e08622' target=_blank style='color:#2F92EE;'>#英国NICE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87086, encryptionId=18bb8e08622, topicName=英国NICE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ce711379167, createdName=lvygwyt2785, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548841, encodeId=1f9115488411d, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=)]
2016-05-30 liuyong2980

#强生#

84 0
[GetPortalCommentsPageByObjectIdResponse(id=1839432, encodeId=0d1c183943243, content=<a href='/topic/show?id=341ae311ea' target=_blank style='color:#2F92EE;'>#FDA批准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7311, encryptionId=341ae311ea, topicName=FDA批准)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Fri Aug 05 19:05:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895903, encodeId=94a118959038a, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Sep 24 11:05:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793779, encodeId=e7641e9377971, content=<a href='/topic/show?id=5a3f1621e7d' target=_blank style='color:#2F92EE;'>#SGLT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16217, encryptionId=5a3f1621e7d, topicName=SGLT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Sat Jun 25 21:05:00 CST 2016, time=2016-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081967, encodeId=b7b1208196e42, content=<a href='/topic/show?id=acf116218e6' target=_blank style='color:#2F92EE;'>#SGLT-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16218, encryptionId=acf116218e6, topicName=SGLT-2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a3a2500014, createdName=fmq_28614553, createdTime=Wed May 10 00:05:00 CST 2017, time=2017-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270833, encodeId=519712e0833f1, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271642, encodeId=a3ad12e16428e, content=<a href='/topic/show?id=2c6c501e578' target=_blank style='color:#2F92EE;'>#强生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50175, encryptionId=2c6c501e578, topicName=强生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288928, encodeId=a6c91288928f0, content=<a href='/topic/show?id=077112e9237' target=_blank style='color:#2F92EE;'>#NICE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12792, encryptionId=077112e9237, topicName=NICE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521609, encodeId=3edc1521609b6, content=<a href='/topic/show?id=18bb8e08622' target=_blank style='color:#2F92EE;'>#英国NICE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87086, encryptionId=18bb8e08622, topicName=英国NICE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ce711379167, createdName=lvygwyt2785, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548841, encodeId=1f9115488411d, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Mon May 30 02:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=)]
2016-05-30 fusion

#NICE#

87 0
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2016-05-30 lvygwyt2785

#英国NICE#

82 0
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2016-05-30 xxxx1054

#重磅#

63 0

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本周糖尿病重磅：强生降糖药INVOKAMET获FDA批准一线治疗2型糖尿病，英国NICE推荐3种SGLT-2降糖药

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