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Ann Clin Psychiatry:精神分裂症患者的尿路感染可能会影响患者的认知能力

2020-10-04 MedSci原创 MedSci原创

精神分裂症会增加感染的发生率。既往研究发现,尿路感染(UTI)与急性精神病之间存在关联。本研究调查了一个大型精神分裂症患者队列中UTI的患病率和相关因素,研究结果已在线发表于Ann Clin Psyc

精神分裂症会增加感染的发生率。既往研究发现,尿路感染(UTI)与急性精神病之间存在关联。本研究调查了一个大型精神分裂症患者队列中UTI的患病率和相关因素,研究结果已在线发表于Ann Clin Psychiatry。

研究人员估计了干预效果临床抗精神病试验(CATIE)精神分裂症试验基线访问时的UTI流行率。然后,研究了UTI与炎症标志物、精神病理学和认知之间的关联,控制了潜在的混杂因素。

结果显示,CATIE试验中基线时可能的UTI患病率为1.2%(1,061名参与者中的13名)。与尿液分析正常的参与者(n = 387)相比,校正潜在混杂因素后,UTI是认知综合评分(β = -0.153,P = .002)和工作记忆(β = -0.190,P < .001)(约1个标准差)较差的显著预测因子。可能性尿路感染的参与者和尿液分析正常的参与者之间的精神病理学评分没有差异。

综上所述,该研究结果表明,精神分裂症患者的尿路感染可能对认知产生影响。研究结果提供了有关感染性疾病合并症的额外证据,这可能对精神分裂症患者的治疗具有临床意义。

原始出处:

Joshua ThomasJoseph P McEvoyBrian J Miller. Urinary tract infection, inflammation, and cognition in phase 1 of the Clinical Antipsychotic Trials of Intervention Effectiveness Study. Ann Clin Psychiatry. 2019 Nov;31(4):242-248.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1792192, encodeId=8c921e921926f, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Jun 08 09:27:14 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969700, encodeId=6a8d969e0094, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=304f5393712, createdName=ms1000000258303035, createdTime=Sun May 30 22:41:39 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915072, encodeId=ff6b9150e27f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 22:14:28 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890563, encodeId=8d7b89056370, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/10/14/1cb55eb1114ec9230e6122d92cd4f535.jpg, createdBy=58b45201202, createdName=1473cbadm77暂无昵称, createdTime=Wed Oct 07 20:37:02 CST 2020, time=2020-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404128, encodeId=ccc31404128de, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Oct 06 07:27:14 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890114, encodeId=94fd8901143d, content=<a href='/topic/show?id=c9bfe649471' target=_blank style='color:#2F92EE;'>#精神分裂症#</a>会增加<a href='/topic/show?id=cfd353291f3' target=_blank style='color:#2F92EE;'>#感染#</a>的发生率, beContent=null, objectType=article, channel=null, level=null, likeNumber=246, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76494, encryptionId=c9bfe649471, topicName=精神分裂症), TopicDto(id=53291, encryptionId=cfd353291f3, topicName=感染)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Oct 04 21:56:12 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2021-05-30 ms1000000258303035

    学到了

    0

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    2021-01-09 zb1235672

    学习了

    0

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    2020-10-07 1473cbadm77暂无昵称

    学习了

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    2020-10-04 lovetcm

    #精神分裂症#会增加#感染#的发生率

    0

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