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JACC Heart Fail:急性失代偿性心衰(ADHF)患者β受体阻滞剂治疗不能停

2015-08-10 徐媛媛译 MedSci原创

以往的研究中,显示停用β受体阻滞剂会增加急性失代偿性心衰(ADHF)患者的死亡率和再入院风险,但并没有进行全面的分析。本研究评估并分析了β受体阻滞剂对急性失代偿性心衰(ADHF)患者的影响。 研究人员通过检索PubMed, EMBASE和COCHRANE电子数据库收纳了来自2000年到2015年1月期间发表的相关研究,这些研究主要比较继续和中断β受体阻滞剂治疗的急性失代偿性心衰研究。 共5项观

以往的研究中,显示停用β受体阻滞剂会增加急性失代偿性心衰(ADHF)患者的死亡率和再入院风险,但并没有进行全面的分析。本研究评估并分析了β受体阻滞剂对急性失代偿性心衰(ADHF)患者的影响。

研究人员通过检索PubMed, EMBASE和COCHRANE电子数据库收纳了来自2000年到2015年1月期间发表的相关研究,这些研究主要比较继续和中断β受体阻滞剂治疗的急性失代偿性心衰研究。

共5项观察性研究和一项随机对照试验, 2704名患者持续β受体阻滞剂治疗,439名病人中断β受体阻滞剂治疗。2项研究显示,中断β受体阻滞剂治疗与院内死亡风险升高显著相关(RR = 3.72; 95% CI, 1.51-9.14)。4项研究显示,中断β受体阻滞剂治疗与短期死亡风险升高显著相关(RR = 1.61; 95% CI, 1.04-2.79)。4项研究显示,中断β受体阻滞剂治疗与短期再入院和/或死亡风险升高显著相关(RR = 1.59; 95% CI, 1.03-2.45)。

以上研究结果显示,停用β受体阻滞剂治疗可增加急性失代偿性心衰患者的院内死亡风险、短期死亡和再入院风险。为了改善患者预后,应继续给予β受体阻滞剂。

原始出处

Kurt W. Prins, MD, PhD?; John M. Neill, MD?; John O. Tyler, MD?; Peter M. Eckman, MD?; Sue Duval, PhD? .Effects of Beta-Blocker Withdrawal in Acute Decompensated Heart Failure.JACC Heart Fail.2015

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    2015-08-14 zhyy88
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encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Aug 12 00:52:00 CST 2015, time=2015-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35371, encodeId=2d10353e1f7, content=哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37681620908, createdName=MYBT, createdTime=Mon Aug 10 16:28:00 CST 2015, time=2015-08-10, status=1, ipAttribution=)]
    2015-09-13 hbwxf
  4. 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  5. [GetPortalCommentsPageByObjectIdResponse(id=2085713, encodeId=7aa22085e1389, content=<a href='/topic/show?id=723a9e69383' target=_blank style='color:#2F92EE;'>#阻滞剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97693, encryptionId=723a9e69383, topicName=阻滞剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Fri Aug 14 09:52:00 CST 2015, time=2015-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936931, encodeId=99a2193693171, content=<a href='/topic/show?id=97da522614d' target=_blank style='color:#2F92EE;'>#急性失代偿性心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52261, encryptionId=97da522614d, topicName=急性失代偿性心衰)], attachment=null, authenticateStatus=null, 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createdName=12498568m50暂无昵称, createdTime=Wed Aug 12 00:52:00 CST 2015, time=2015-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356000, encodeId=742313560005b, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Aug 12 00:52:00 CST 2015, time=2015-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562315, encodeId=157d1562315bc, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Aug 12 00:52:00 CST 2015, time=2015-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35371, encodeId=2d10353e1f7, content=哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37681620908, createdName=MYBT, createdTime=Mon Aug 10 16:28:00 CST 2015, time=2015-08-10, status=1, ipAttribution=)]
    2015-12-08 gongliu
  6. 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  7. 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  8. 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encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Aug 12 00:52:00 CST 2015, time=2015-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35371, encodeId=2d10353e1f7, content=哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37681620908, createdName=MYBT, createdTime=Mon Aug 10 16:28:00 CST 2015, time=2015-08-10, status=1, ipAttribution=)]
    2015-08-12 zhaojie88
  9. 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    2015-08-12 slcumt
  10. 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    2015-08-10 MYBT

    0

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