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SCI REP:吸烟和饮酒与食管鳞状细胞癌风险之间的关系!

2017-12-09 xing.T MedSci原创

总之,在男性中,饮酒与食管鳞状细胞癌风险之间存在剂量反应关系,这种关系在吸烟者中尤为明显。

以往关于高危地区食管癌风险与吸烟/饮酒之间关系的研究结果并不一致。近日,Scientific reports杂志上针对这一问题发表了一篇研究文章,研究人员从2010年到2013年期间在中国食管癌高发地区进行了一项大样本的病例对照研究

该研究招募了1353例食管癌患者和1961例对照者,吸烟和饮酒的数据是通过采用结构化问卷面对面访谈来进行收集。研究人员采用非条件logistic回归模型来估计比值比(OR)和95%可信区间。

在调整饮酒和其他潜在的混杂因素后,重度吸烟男性(即那些每天吸烟超过20支香烟或40包每年或开始吸烟较早)食管鳞状细胞癌的风险适度增加;然而,当前吸烟与增加的风险无关。在男性中饮酒会明显增加食管癌的风险(OR=2.20,95%可信区间为1.79-2.70)。研究人员观察到,随着开始饮酒年龄的减少和酒精摄入的持续时间和摄入量的增加,食管癌风险增加,这在当前吸烟者中尤为明显。相反,在女性中,吸烟和饮酒与食管癌风险无关。

总之,在男性中,饮酒与食管鳞状细胞癌风险之间存在剂量反应关系,这种关系在吸烟者中尤为明显。

原始出处:

Xiaorong Yang,et al. Smoking and alcohol drinking in relation to the risk of esophageal squamous cell carcinoma: A population-based case-control study in China.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-17617-2

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    2018-02-01 sjq027
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    2017-12-14 wzb521zf

    一起学习一下

    0

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    2017-12-11 zhouqu_8

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