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Neurology:类风湿性关节炎母亲生出的宝宝更容易发生癫痫!

2016-11-17 haofan MedSci原创

由此可见,暴露于母亲类风湿性关节炎与儿童发生癫痫的风险增加相关,而暴露于父亲的类风湿性关节炎与儿童发生癫痫的风险不存在相关性,这表明在宫内环境的变化可能发挥着重要作用。

近日,神经病学领域权威杂志Neurology上发表了来自丹麦哥本哈根大学妇女儿童健康研究所的Ane Lilleøre Rom博士及其团队的一篇研究文章,旨在评估父母类风湿性关节炎对后代癫痫发作风险的影响。 

研究人员进行了一项全国性队列研究,纳入了所有在1977年至2008年之间出生于丹麦的单胎儿作为研究对象(n=1,917,723),通过个人联系到了丹麦全国登记中心。研究人员对这些孩子平均随访了16年,该研究的主要结局指标为儿童早期(16天到4岁)、儿童晚期(5岁到15岁)、青少年/成年(≥15岁)和随访结束(2010年12月31日)前的任何年龄癫痫发生的调整后风险比。 

研究人员发现相比于母亲无类风湿性关节炎的儿童,其母亲患有类风湿性关节炎的儿童在儿童早期和晚期发生癫痫的风险显著增加(儿童早期调整后的风险比为1.34[95%置信区间为1.13–1.60];儿童晚期调整后的风险比为1.26[95%可信区间为1.13–1.41]),然而其母亲患有类风湿性关节炎的儿童在青少年/成年发生癫痫的风险并没有增加(风险比为1.15[95%可信区间为0.92–1.45])。


同时,研究者还发现父亲患有类风湿性关节炎与后代整体的或在任何年龄的癫痫风险不相关(风险比为0.96 [ 95%可信区间为0.81–1.15])。相比于母亲在后代出生后才诊断为类风湿性关节炎的儿童,在宫内期间就暴露于母亲类风湿性关节炎发作的儿童在儿童早期发生癫痫的风险增加的更明显(风险比为1.90 [95%可信区间为1.26-2.86) vs. 风险比为1.26 [95%可信区间为1.03-1.52],P=0.16)。

由此可见,暴露于母亲类风湿性关节炎与儿童发生癫痫的风险增加相关,而暴露于父亲类风湿性关节炎与儿童发生癫痫的风险不存在相关性,这表明在宫内环境的变化可能发挥着重要作用。

原始出处:

Ane Lilleøre Rom, et al. Parental rheumatoid arthritis and childhood epilepsyA nationwide cohort study.2016. Neurology.November 16, 2016.

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483423, encodeId=c4401483423dc, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2017-02-02 yinhl1978
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    2016-12-13 虈亣靌

    这个不错,学习了

    0

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href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333838, encodeId=022b1333838a8, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483423, encodeId=c4401483423dc, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2016-12-02 虈亣靌

    讲的好,学习了

    0

  4. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483423, encodeId=c4401483423dc, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2016-11-22 susice

    需要关注一下

    0

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483423, encodeId=c4401483423dc, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2016-11-21 ylzr123

    暴露于母亲类风湿性关节炎与儿童发生癫痫的风险增加相关,而暴露于父亲类风湿性关节炎与儿童发生癫痫的风险不存在相关性,这表明在宫内环境的变化可能发挥着重要作用。

    0

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483423, encodeId=c4401483423dc, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2016-11-19 邓启付

    患类风湿性关节炎母亲与儿童患类风湿性关节炎有没有关系啊

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Sat Nov 19 17:03:28 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156884, encodeId=a6e61568842c, content=母亲患类风湿性关节炎与儿童早期发生癫痫的风险增加,与父亲患病无关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Sat Nov 19 17:02:31 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265361, encodeId=a6211265361e6, content=<a 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483423, encodeId=c4401483423dc, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2016-11-19 邓启付

    母亲患类风湿性关节炎与儿童早期发生癫痫的风险增加,与父亲患病无关。

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Sat Nov 19 17:03:28 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156884, encodeId=a6e61568842c, content=母亲患类风湿性关节炎与儿童早期发生癫痫的风险增加,与父亲患病无关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Sat Nov 19 17:02:31 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265361, encodeId=a6211265361e6, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333838, encodeId=022b1333838a8, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483423, encodeId=c4401483423dc, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Sat Nov 19 12:59:00 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2016-11-19 lmm397
  9. 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