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GUT:粪便血红蛋白阳性与多种疾病死亡风险增加相关

2018-07-19 zhangfan MedSci原创

可检测的粪便血红蛋白与多种疾病死亡风险增加相关

一般认为可检测的粪便血红蛋白(f-Hb)与结直肠癌(CRC)和全因死亡风险之间存在关联。近日研究人员在英国患者队列研究中验证愈伤组织粪便潜血试验(GFOBT)结果阳性与结肠癌死亡之间的关联。

2000-16年间,134192名gFOBT筛查人群参与研究,记录参与者筛查结果并考察结果与参与者死亡之间的关系。

总计2714名参与者筛查结果为阳性,相对于阴性人群,在调整性别、年龄以及药物出血因素后,阳性人群的CRC死亡(HR=7.79)以及非CRC死亡(HR=1.58)风险增加, p<0.0001。此外gFOBT检测法f-Hb阳性人群的循环系统、呼吸系统、消化系统疾病(不包括CRC)、神经心理疾病、血液和内分泌疾病以及非CRC疾病死亡风险增加。

研究发现,可检测的粪便血红蛋白与多种疾病死亡风险增加相关。

原始出处:


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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-08-05 青山颖钰

    学习了

    0

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    2018-07-27 GZphD9

    学习了

    0

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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下,有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-07-20 Homburg
  5. 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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下,有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-20 huangdf
  6. 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  7. 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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下,有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-19 Jackie Li

    学习

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=1557154, encodeId=9f17155e1546b, content=<a href='/topic/show?id=8e2ae632643' target=_blank style='color:#2F92EE;'>#粪便血红蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76326, encryptionId=8e2ae632643, topicName=粪便血红蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d90d14863929, createdName=psybestwish, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466828, encodeId=00731466828e2, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1371927, encodeId=3f1b13e19274d, content=<a href='/topic/show?id=815e2e060ce' target=_blank style='color:#2F92EE;'>#便血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27060, encryptionId=815e2e060ce, topicName=便血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255782, encodeId=f55e1255e820b, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下,有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-19 明崖

    学习下,有用的研究

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=336486, encodeId=5518336486d8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Sun Aug 05 06:41:44 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334456, encodeId=1d8a33445692, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/07/09/9d6ae4a345db0c5799f866ac5743fbc0.jpg, createdBy=0ba62073690, createdName=GZphD9, createdTime=Fri Jul 27 07:50:07 CST 2018, time=2018-07-27, status=1, ipAttribution=), 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createdBy=03cc6863823, createdName=Homburg, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1371927, encodeId=3f1b13e19274d, content=<a href='/topic/show?id=815e2e060ce' target=_blank style='color:#2F92EE;'>#便血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27060, encryptionId=815e2e060ce, topicName=便血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255782, encodeId=f55e1255e820b, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下,有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-19 牛顿爱吃苹果

    学习了

    0

  10. 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createdBy=03cc6863823, createdName=Homburg, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1371927, encodeId=3f1b13e19274d, content=<a href='/topic/show?id=815e2e060ce' target=_blank style='color:#2F92EE;'>#便血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27060, encryptionId=815e2e060ce, topicName=便血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255782, encodeId=f55e1255e820b, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下,有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-19 lary

    学习了

    0

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