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Ann Surg Oncol:非气腹腹腔镜辅助经膈食管癌切除术疗效有待证实

2014-10-27 付校 丁香园

经膈食管切除术并发症较低。为了探讨非气腹腹腔镜辅助下经膈手术治疗新辅助化疗后胸上端或颈段食管癌的疗效,观察该手术是否并发症较低。来自北京同仁医院于磊教授等对此进行了研究,文章最近发表在ASO上。 该研究纳入2011年-2013年同仁医院胸外科的11例胸上端或颈段食管癌患者进行了回顾性分析。这些患者均接受了新辅助化疗。8例为颈段食管癌,3例为胸上端食管癌。这些患者均为接受了术前化疗。

经膈食管切除术并发症较低。为了探讨非气腹腹腔镜辅助下经膈手术治疗新辅助化疗后胸上端或颈段食管癌的疗效,观察该手术是否并发症较低。来自北京同仁医院于磊教授等对此进行了研究,文章最近发表在ASO上。

该研究纳入2011年-2013年同仁医院胸外科的11例胸上端或颈段食管癌患者进行了回顾性分析。这些患者均接受了新辅助化疗。8例为颈段食管癌,3例为胸上端食管癌。这些患者均为接受了术前化疗。

上腹部行5个腹腔镜切口及左颈部一4cm切口。采用单腔气管插管机械通气。手术第一阶段通过腹壁提升器建立无气腹腔镜空间(图1)。除了剑突下一4cm切口便于塞棉球或纱布外,其他4个切口均为传统的套针切口(图2)。

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图1:腹壁提升器建立非气腹腹腔镜

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图2:上腹部5个腹腔镜切口

手术第一步是用超声刀松解胃周韧带。松解胃结肠韧带时应小心保留胃网膜右血管。分离胃短血管要特别小心。接着暴露胃肝韧带。然后切开左右膈肌角进入下纵膈。腹段食管周围被全部分离。暴露胃小弯处胃左动静脉,在其起源处用Endo-GIA予以横断。

沿大弯侧用直线切割器裁宽约5cm的管状胃。在左颈部游离食管后,钝性拔除胸腔内食管,同时,下端食管在胃食管连接处用超声刀予以切断。将纱布带缝于胃管并送至颈部。通过牵引纱布带将远端食管通过后纵膈牵至颈部(图3)。然后通过将纱布压于食管床周围(图4)。在颈部行食管胃吻合术并行颈部淋巴结清扫术。

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图3:通过后纵隔向颈部拔脱的食管

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图4:纱布垫于后纵隔食管床

该研究无手术相关死亡或中转开胸。平均手术时间为146.0±22.2min。术中平均出血量为192.7±25.5 ml。3例发生吻合口漏,1例发生肺部并发症,2例发生心血管并发症及1例部分结肠疝入右胸腔。2例患者接受术后辅助放疗。所有患者随访时间为6个月至3.5年。随访期间,3例患发生≥1次的肺部并发症。所有患者术后均有烧心和返流症状。生存率为63.6%。

该研究表明,新辅助化疗后,非气腹腹腔镜辅助的经膈食管切除术为胸上/颈段食管癌提供了一个微创治疗方法。但似乎术后并发症相对较高。需进一步研究以确定是否可以提高长期生存率。

原始出处:

Wu JX1, Yu L, Li JY, Zhang YF, Ke J.Gasless Laparoscopically Assisted Transhiatal Esophagectomy for Upper Esophageal Carcinoma.Ann Surg Oncol. 2014 Sep 18. [Epub ahead of print]

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    2015-09-26 JR19860227
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    2015-05-22 minlingfeng
  5. [GetPortalCommentsPageByObjectIdResponse(id=1810604, encodeId=510918106044f, content=<a href='/topic/show?id=37548564230' target=_blank style='color:#2F92EE;'>#腹腔镜辅助#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85642, encryptionId=37548564230, topicName=腹腔镜辅助)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=bnjfy, createdTime=Thu Jul 23 03:50:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651412, encodeId=74e1165141216, content=<a href='/topic/show?id=350d6385879' target=_blank style='color:#2F92EE;'>#气腹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63858, encryptionId=350d6385879, topicName=气腹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=488224195930, createdName=JR19860227, createdTime=Sat Sep 26 04:50:00 CST 2015, time=2015-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820908, encodeId=5ba518209080e, content=<a href='/topic/show?id=fe6610109450' target=_blank style='color:#2F92EE;'>#食管癌切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101094, encryptionId=fe6610109450, topicName=食管癌切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Nov 13 17:50:00 CST 2014, time=2014-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864549, encodeId=39d9186454983, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 22 14:50:00 CST 2015, time=2015-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1876686, encodeId=131918e6686bb, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Tue Mar 24 20:50:00 CST 2015, time=2015-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276335, encodeId=8b2212e633536, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Wed Oct 29 01:50:00 CST 2014, time=2014-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437077, encodeId=7136143e07759, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Oct 29 01:50:00 CST 2014, time=2014-10-29, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1810604, encodeId=510918106044f, content=<a href='/topic/show?id=37548564230' target=_blank style='color:#2F92EE;'>#腹腔镜辅助#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85642, encryptionId=37548564230, topicName=腹腔镜辅助)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=bnjfy, createdTime=Thu Jul 23 03:50:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651412, encodeId=74e1165141216, content=<a href='/topic/show?id=350d6385879' target=_blank style='color:#2F92EE;'>#气腹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63858, encryptionId=350d6385879, topicName=气腹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=488224195930, createdName=JR19860227, createdTime=Sat Sep 26 04:50:00 CST 2015, time=2015-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820908, encodeId=5ba518209080e, content=<a href='/topic/show?id=fe6610109450' target=_blank style='color:#2F92EE;'>#食管癌切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101094, encryptionId=fe6610109450, topicName=食管癌切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Nov 13 17:50:00 CST 2014, time=2014-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864549, encodeId=39d9186454983, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 22 14:50:00 CST 2015, time=2015-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1876686, encodeId=131918e6686bb, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Tue Mar 24 20:50:00 CST 2015, time=2015-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276335, encodeId=8b2212e633536, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Wed Oct 29 01:50:00 CST 2014, time=2014-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437077, encodeId=7136143e07759, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Oct 29 01:50:00 CST 2014, time=2014-10-29, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1810604, encodeId=510918106044f, content=<a href='/topic/show?id=37548564230' target=_blank style='color:#2F92EE;'>#腹腔镜辅助#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85642, encryptionId=37548564230, topicName=腹腔镜辅助)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=bnjfy, createdTime=Thu Jul 23 03:50:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651412, encodeId=74e1165141216, content=<a href='/topic/show?id=350d6385879' target=_blank style='color:#2F92EE;'>#气腹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63858, encryptionId=350d6385879, topicName=气腹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=488224195930, createdName=JR19860227, createdTime=Sat Sep 26 04:50:00 CST 2015, time=2015-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820908, encodeId=5ba518209080e, content=<a href='/topic/show?id=fe6610109450' target=_blank style='color:#2F92EE;'>#食管癌切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101094, encryptionId=fe6610109450, topicName=食管癌切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Nov 13 17:50:00 CST 2014, time=2014-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864549, encodeId=39d9186454983, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 22 14:50:00 CST 2015, time=2015-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1876686, encodeId=131918e6686bb, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Tue Mar 24 20:50:00 CST 2015, time=2015-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276335, encodeId=8b2212e633536, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Wed Oct 29 01:50:00 CST 2014, time=2014-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437077, encodeId=7136143e07759, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Oct 29 01:50:00 CST 2014, time=2014-10-29, status=1, ipAttribution=)]
    2014-10-29 zhouqu_8
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