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Lancet Gastroenterol Hepatol:关注炎性肠病患者焦虑抑郁,改善预后

2021-03-27 MedSci原创 MedSci原创

鼓励胃肠病专家筛查和治疗这些焦虑抑郁症状可能会改善IBD患者的预后。

炎性肠病(IBD)是一种无法治愈的终生疾病。IBD患者可能会出现常见的精神障碍症状,如焦虑和抑郁,这是因为通过肠道-脑轴的双向沟通和症状的慢性化,以及生活质量下降和社会功能降低。然而,这个问题的严重程度仍然存在不确定性。Barberio评估了成人IBD患者焦虑或抑郁症状的患病率,文章发表在Lancet Gastroenterol Hepatol杂志

这项系统回顾和荟萃分析在MEDLINEEmbaseEmbase ClassicMental INFO上搜索从最初到2020930日发表的论文,报道了招募了至少100名成年IBD患者的观察性研究,并根据有效的筛查工具报告了焦虑或抑郁症状的患病率。排除了只使用结构化访谈来评估这些症状以及没有提供可提取数据的研究。从已发表的研究报告中提取数据,计算焦虑和抑郁症状的合并患病率、优势比(OR)95%置信区间。

在已确定的5544项研究中,77项符合资格标准,包括总共30118名患者。在58项研究(I2=96.9%)中,焦虑症状的综合患病率为32.1%(95%CI 28.3~36.0);在75项研究中(I2=97.6%),抑郁症状的综合患病率为25.2%(22.0~28.5)。在报道同一研究人群中克罗恩病和溃疡性结肠炎患者焦虑或抑郁患病率的研究中,克罗恩病患者出现焦虑症状(OR 1.295%CI 1.1~1.4)和抑郁症状(1.21.1~1.4)的几率比溃疡性结肠炎患者高。总体而言,女性IBD患者比男性IBD患者更容易出现焦虑症状(合并患病率:女性为33.8%[95%CI 26.5-41.5],男性为22.8%[18.7-27.2]OR 1.7[95%可信区间1.2-2.3])。女性也比男性更容易出现抑郁症状(合并患病率:女性为21.2%[95%CI 15.4-27.6],男性16.2%[12.6-20.3]OR 1.3[95%CI 1.0-1.8])。活动期IBD患者焦虑(57·6%[95%CI 38·6-75·4])或抑郁症状(38·9%[26·2-52·3])的患病率高于非活动期疾病患者(焦虑38.1%[30.9-45.7]、抑郁24.2%[14.7-35.3]);焦虑OR 2.5[95%CI 1.5-4.1]、抑郁OR 3.1[1.9-4]

综上所述,IBD患者中焦虑和抑郁症状的发生率很高,多达三分之一的患者受到焦虑症状的影响,四分之一的患者受到抑郁症状的影响。活动性疾病患者的患病率有所增加:这些患者中有一半符合焦虑症状的标准,三分之一符合抑郁症状的标准。鼓励胃肠病专家筛查和治疗这些焦虑抑郁症状可能会改善IBD患者的预后。

原文出处:

Barberio, Brigida et al. “Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis.” The lancet. Gastroenterology & hepatology, S2468-1253(21)00014-5. 12 Mar. 2021, doi:10.1016/S2468-1253(21)00014-5

 

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    2021-08-06 howi
  3. 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    2021-11-08 许安
  4. 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  5. 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objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Mar 28 00:11:51 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
    2021-07-01 王子燕窝

    好文章

    0

  6. 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  7. 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objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Mar 28 00:11:51 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
    2021-03-29 gwc384
  8. [GetPortalCommentsPageByObjectIdResponse(id=2065299, encodeId=3f3d2065299d8, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Jul 27 20:11:51 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1831087, encodeId=08f3183108edf, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Feb 11 15:11:51 CST 2022, time=2022-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978718, encodeId=4fa59e871842, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210701/744f639c0ac24549ab1e0c4fbb6876ed/9afc870f9e0d45a0963b7dae6cc8c8b2.jpg, createdBy=11b55161224, createdName=王子燕窝, createdTime=Thu Jul 01 20:01:56 CST 2021, time=2021-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029232, encodeId=74ee202923233, content=<a href='/topic/show?id=63e56e285dd' target=_blank style='color:#2F92EE;'>#焦虑抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67285, encryptionId=63e56e285dd, topicName=焦虑抑郁)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/17F844FBE270B8196CB4C53EC9493C57/100, createdBy=9d712500079, createdName=ms5906905816781247, createdTime=Mon Dec 20 08:11:51 CST 2021, time=2021-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427502, encodeId=4694142e5028a, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Mon Mar 29 12:11:51 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951795, encodeId=ceb7951e9540, content=我学到了很多东西谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5b3006368, createdName=1436749007, createdTime=Sun Mar 28 09:59:24 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034238, encodeId=f551103423866, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sun Mar 28 00:11:51 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050550, encodeId=34df1050550db, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Mar 28 00:11:51 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
    2021-03-28 1436749007

    我学到了很多东西谢谢老师

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2065299, encodeId=3f3d2065299d8, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Jul 27 20:11:51 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1831087, encodeId=08f3183108edf, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Feb 11 15:11:51 CST 2022, time=2022-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978718, encodeId=4fa59e871842, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210701/744f639c0ac24549ab1e0c4fbb6876ed/9afc870f9e0d45a0963b7dae6cc8c8b2.jpg, createdBy=11b55161224, createdName=王子燕窝, createdTime=Thu Jul 01 20:01:56 CST 2021, time=2021-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029232, encodeId=74ee202923233, content=<a href='/topic/show?id=63e56e285dd' target=_blank style='color:#2F92EE;'>#焦虑抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67285, encryptionId=63e56e285dd, topicName=焦虑抑郁)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/17F844FBE270B8196CB4C53EC9493C57/100, createdBy=9d712500079, createdName=ms5906905816781247, createdTime=Mon Dec 20 08:11:51 CST 2021, time=2021-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427502, encodeId=4694142e5028a, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Mon Mar 29 12:11:51 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951795, encodeId=ceb7951e9540, content=我学到了很多东西谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5b3006368, createdName=1436749007, createdTime=Sun Mar 28 09:59:24 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034238, encodeId=f551103423866, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sun Mar 28 00:11:51 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050550, encodeId=34df1050550db, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Mar 28 00:11:51 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
    2021-03-28 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2065299, encodeId=3f3d2065299d8, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Jul 27 20:11:51 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1831087, encodeId=08f3183108edf, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, 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GetPortalCommentsPageByObjectIdResponse(id=951795, encodeId=ceb7951e9540, content=我学到了很多东西谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5b3006368, createdName=1436749007, createdTime=Sun Mar 28 09:59:24 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034238, encodeId=f551103423866, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sun Mar 28 00:11:51 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050550, encodeId=34df1050550db, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Mar 28 00:11:51 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
    2021-03-28 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

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