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JACC:高浓度肌钙蛋白可增加心血管疾病风险!

2017-07-31 MedSci MedSci原创

目前,通过敏感度高的检测手段可以检测无明显临床心梗症状病人的肌酐蛋白I和T(hs-cTnI, hs-cTnT)的含量。近日,在国际心血管权威杂志JACC上发表了一篇旨在评估初次干预的患者的心血管疾病(CVD)预后与心脏肌酐蛋白浓度相关性的临床研究。本研究搜索并分析了PubMed, Web of Science,和EMBASE数据库截至2016年9月份发表的关于心脏肌钙蛋白浓度和心血管疾病预后(比如

目前,通过敏感度高的检测手段可以检测无明显临床心梗症状病人的肌酐蛋白I和T(hs-cTnI, hs-cTnT)的含量。近日,在国际心血管权威杂志JACC上发表了一篇旨在评估初次干预的患者的心血管疾病(CVD)预后与心脏肌酐蛋白浓度相关性的临床研究。本研究搜索并分析了PubMed, Web of Science,和EMBASE数据库截至2016年9月份发表的关于心脏肌钙蛋白浓度和心血管疾病预后(比如冠心病、中风或者两者都有)相关性的临床研究。最终分析了28个符合条件的研究,共纳入154052名研究对象。心脏肌钙蛋白在80%的研究对象中能检测出来(hs-cTnI: 82.6%; hs-cTnT: 69.7%)。在普伐他汀在老年人血管疾病危险性研究中的应用(PROSPER)的数据库中,hs-cTnT和心血管疾病预后呈对数正相关性。在荟萃分析中,肌钙蛋白对心血管疾病的相对风险为1.43 (95% [CI]: 1.31-1.56),对致命的CVD(7775例)为1.67(95% CI: 1.50-1.86),对冠心病(7061例)的风险为1.59 (95% CI: 1.38-1.83),对中风(

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  1. 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topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Aug 02 07:35:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473065, encodeId=489914e3065a6, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Wed Aug 02 07:35:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498256, encodeId=09f6149825625, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, 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content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Aug 02 07:29:27 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228748, encodeId=409f228e4837, content=文章好好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Aug 01 09:08:20 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228736, encodeId=3749228e36b0, content=正常范围内的高肌钙蛋白浓度与心血管疾病风险增加有关,是不是表明有轻微的损伤?, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Aug 01 08:47:31 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2018-02-22 周周人

    学习.

    0

  2. 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topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Aug 02 07:35:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473065, encodeId=489914e3065a6, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Wed Aug 02 07:35:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498256, encodeId=09f6149825625, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Aug 02 07:35:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544458, encodeId=1f281544458a0, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Wed Aug 02 07:35:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229060, encodeId=4504229060a5, 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2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228736, encodeId=3749228e36b0, content=正常范围内的高肌钙蛋白浓度与心血管疾病风险增加有关,是不是表明有轻微的损伤?, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Aug 01 08:47:31 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-10-22 hbwxf
  3. 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topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Aug 02 07:35:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473065, encodeId=489914e3065a6, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Wed Aug 02 07:35:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498256, encodeId=09f6149825625, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, 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2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228736, encodeId=3749228e36b0, content=正常范围内的高肌钙蛋白浓度与心血管疾病风险增加有关,是不是表明有轻微的损伤?, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Aug 01 08:47:31 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-08-27 周周人

    学习.

    0

  4. 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  5. 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content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Aug 02 07:29:27 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228748, encodeId=409f228e4837, content=文章好好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Aug 01 09:08:20 CST 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  6. 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  7. 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  8. 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2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228736, encodeId=3749228e36b0, content=正常范围内的高肌钙蛋白浓度与心血管疾病风险增加有关,是不是表明有轻微的损伤?, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Aug 01 08:47:31 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-08-02 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

  9. 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2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228736, encodeId=3749228e36b0, content=正常范围内的高肌钙蛋白浓度与心血管疾病风险增加有关,是不是表明有轻微的损伤?, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Aug 01 08:47:31 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-08-01 1e10c84am36(暂无匿称)

    文章好好,拜读了

    0

  10. 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2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228736, encodeId=3749228e36b0, content=正常范围内的高肌钙蛋白浓度与心血管疾病风险增加有关,是不是表明有轻微的损伤?, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Aug 01 08:47:31 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-08-01 lovetcm

    正常范围内的高肌钙蛋白浓度与心血管疾病风险增加有关,是不是表明有轻微的损伤?

    0

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