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Kidney int:2型糖尿病患者血液透析后的钠含量如何?

2018-02-21 MedSci MedSci原创

长期升高的血糖水平导致2型糖尿病(T2DM)患者的组织基质组成发生一定的变化。近期,一项发表在杂志Kidney int上的研究进行了一项假设:2型糖尿病的血液透析患者可能比正常血糖的血液透析患者累积更多的组织钠。为了检验这一假设,研究者们使用23Na磁共振成像(23Na MRI)评估有或没有T2DM的血液透析患者的皮肤和肌肉组织中的钠。最终,在10名2型糖尿病的血液透析患者中​​以及30名匹配的对

长期升高的血糖水平导致2型糖尿病(T2DM)患者的组织基质组成发生一定的变化。

近期,一项发表在杂志Kidney int上的研究进行了一项假设:2型糖尿病的血液透析患者可能比正常血糖的血液透析患者累积更多的组织钠。为了检验这一假设,研究者们使用23Na磁共振成像(23Na MRI)评估有或没有T2DM的血液透析患者的皮肤和肌肉组织中的钠。

最终,在10名2型糖尿病的血液透析患者中​​以及30名匹配的对照血液透析患者中​​,在血液透析前后,通过1HMRI评估了患者肌肉脂肪含量,通过23NaMRI评估了组织钠含量。此外,还使用Body Composition Monitor评估了患者的体液分布。 

此项研究结果显示:与非糖尿病血液透析患者相比,1H MRI显示出T2DM血液透析患者肌肉脂肪含量更高。 与对照血液透析患者相比,23Na MRI显示出患有T2DM的血液透析患者的肌肉和皮肤组织中的钠含量增加。

使用多频生物阻抗用于估计细胞外水(ECW),结果显示T2DM血液透析患者的过量ECW与HbA1c水平相关。血液透析过程中的钠动员使T2DM血液透析患者的透析后肌肉钠含量较对照血液透析患者降低更多。

此项研究结果表明,2型糖尿病的血液透析患者钠蓄积增加,并且血糖代谢受损与组织钠和水含量紊乱有关。

原始出处:
Kopp C, Linz P, et al. Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging. Kidney Int. 2018 Feb 15. pii: S0085-2538(17)30857-8. doi: 10.1016/j.kint.2017.11.021. 

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    2018-02-25 溜溜梅不酸

    学习了

    0

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    2018-02-23 habb
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  5. 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createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 21 15:51:16 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289715, encodeId=452f289e152d, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Feb 21 15:35:42 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289705, encodeId=06b5289e05f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Feb 21 11:47:05 CST 2018, time=2018-02-21, status=1, ipAttribution=)]
    2018-02-23 gwc389
  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Feb 21 11:47:05 CST 2018, time=2018-02-21, status=1, ipAttribution=)]
    2018-02-21 明崖

    学习了.有趣的研究

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Feb 21 11:47:05 CST 2018, time=2018-02-21, status=1, ipAttribution=)]
    2018-02-21 惠映实验室

    学习..谢谢分享.

    0

  8. 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createdBy=73441710184, createdName=明崖, createdTime=Wed Feb 21 23:46:44 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289728, encodeId=af72289e288b, content=学习..谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Feb 21 16:59:33 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289721, encodeId=6597289e2188, content=学习了.收益很大., beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 21 15:51:16 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289715, encodeId=452f289e152d, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Feb 21 15:35:42 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289705, encodeId=06b5289e05f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Feb 21 11:47:05 CST 2018, time=2018-02-21, status=1, ipAttribution=)]
    2018-02-21 1e0f8808m18(暂无匿称)

    学习了.收益很大.

    0

  9. 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createdBy=73441710184, createdName=明崖, createdTime=Wed Feb 21 23:46:44 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289728, encodeId=af72289e288b, content=学习..谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Feb 21 16:59:33 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289721, encodeId=6597289e2188, content=学习了.收益很大., beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 21 15:51:16 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289715, encodeId=452f289e152d, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Feb 21 15:35:42 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289705, encodeId=06b5289e05f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Feb 21 11:47:05 CST 2018, time=2018-02-21, status=1, ipAttribution=)]
    2018-02-21 清风拂面

    谢谢分享学习

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Feb 21 11:47:05 CST 2018, time=2018-02-21, status=1, ipAttribution=)]
    2018-02-21 183****7028

    学习

    0

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