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Medicine:脓胸可致主动脉夹层动脉瘤发生的增加

2015-12-27 MedSci MedSci原创

脓胸(PE)可能演变为坏死,胸腔瘘,脓毒症;因此,它也与高死亡率相关。研究者调查分析了PE患者主动脉夹层动脉瘤的风险(AA)。在PE队列研究中,共有PE患者34250名患者,137000名非PE的患者作为对照组,按照性别,年龄和PE诊断指标年进行配对。排除20岁以下,存在主动脉夹层动脉瘤风险的患者。应用Cox比率风险回归模型对AA进行分析。与非PE患者相比,PE患者中AA发生的风险增高1.69倍(

脓胸(PE)可能演变为坏死,胸腔瘘,脓毒症;因此,它也与高死亡率相关。研究者调查分析了PE患者主动脉夹层动脉瘤的风险(AA)。

在PE队列研究中,共有PE患者34250名患者,137000名非PE的患者作为对照组,按照性别,年龄和PE诊断指标年进行配对。排除20岁以下,存在主动脉夹层动脉瘤风险的患者。应用Cox比率风险回归模型对AA进行分析。与非PE患者相比,PE患者中AA发生的风险增高1.69倍(aHR = 1.69; 95%CI = 1.39-2.05)。在研究分析中,即使不存在9中共发病(糖尿病高血压,高血脂,慢性阻塞性肺疾病,心衰,心血管疾病,卒中,细菌性心内膜炎和风湿性心内膜炎),PE患者AA发生的校正HR升高(aHR = 2.01;95%CI = 1.44-2.81)。与没有9种共发病或PE的患者,仅存在PE的患者发生AA的风险增加(aHR = 2;95%CI = 1.43-2.79)。在随访的12年中,与非PE患者相比,PE患者AA的累积发生率显著升高。

在大型的队列研究中,PE患者与AA发生的风险升高。

原文出处:

Wu CY, Su TW, Huang KY, et al. Pleural Empyema and Aortic Aneurysm: A Retrospective National Population-Based Cohort Study. Medicine (Baltimore). 2015 Nov.

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    2016-06-03 jeanqiuqiu
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    2016-09-03 doctorJiangchao

    继续学习

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    2016-09-03 doctorJiangchao

    继续关注

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    2016-09-12 kalseyzl
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