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JCEM:术前BMI预测成人发病的颅咽管瘤患者术后体重增加

2021-01-20 MedSci原创 MedSci原创

在这个AOCP患者队列中,术前随访时BMI较低的患者术后体重增加较多。该研究的结果可能有助于医生更好地指导患者。

颅咽管瘤虽然是良性的,但在所有非恶性的鞍区肿瘤中发病率最高。对于成人发病的颅咽管瘤(AOCP)患者体重和代谢结局的研究并不多。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在评估AOCP患者术后体重和代谢结局,并确定体重增加的临床预测因素。

研究人员回顾性地分析了2014年1月至2019年5月期间在单一垂体中心进行手术的AOCP患者。45例AOCP患者,至少随访3个月。中位随访时间为26个月(IQR为10-44)。该研究的主要结局指标为术前和最后一次随访记录的体重/BMI、代谢合并症和垂体缺陷情况。

最后一次随访时,体重和BMI均升高,体重平均增加3.4 kg (p=0.015), BMI平均增加1.15 kg/m2 (p=0.0095)。体重变化中位数为2.7% (IQR为-1.1%,8.8%)。肥胖率从基线的37.8%上升到最后一次随访的55.6%。三分之一的患者体重增加的中位数约为15%。最后一次随访时的代谢合并症患病率与基线无差异。术后垂体缺陷的发生比例增加,58%的患者存在3个以上激素分泌不足。术前BMI与术后体重增加呈负相关,在调整年龄、性别、种族、肿瘤和治疗特点后,体重增加仍然显著。最后一次随访时3个以上激素分泌不足的患者术后体重增加也较高。

在这个AOCP患者队列中,术前随访时BMI较低的患者术后体重增加较多。该研究的结果可能有助于医生更好地指导患者

原始出处:

Daisy Duan.et al.Preoperative BMI Predicts Postoperative Weight Gain in Adult-Onset Craniopharyngioma.JCEM.2021.https://pubmed.ncbi.nlm.nih.gov/33417676/

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    2021-04-30 smallant2015
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    2021-09-04 achengzhao
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    2021-01-27 1257c336m18暂无昵称

    怎么不来积分了。好奇怪

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1778008, encodeId=75e41e7800850, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Fri Apr 30 19:32:48 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063390, encodeId=79452063390b6, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Sep 04 07:32:48 CST 2021, time=2021-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920414, encodeId=8db49204146f, content=怎么不来积分了。好奇怪, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01f52568974, createdName=1257c336m18暂无昵称, createdTime=Wed Jan 27 20:27:11 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298246, encodeId=ebc01298246a5, content=<a href='/topic/show?id=3379266918f' target=_blank style='color:#2F92EE;'>#体重增加#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26691, encryptionId=3379266918f, topicName=体重增加)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Fri Jan 22 13:32:48 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511906, encodeId=1fa715119067f, content=<a href='/topic/show?id=fd34100438e0' target=_blank style='color:#2F92EE;'>#颅咽管瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100438, encryptionId=fd34100438e0, topicName=颅咽管瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c66710405355, createdName=ms8435843352634314, createdTime=Fri Jan 22 13:32:48 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918861, encodeId=03ad91886102, content=进来学习一下了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Thu Jan 21 23:32:22 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918579, encodeId=62ad9185e9af, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acfe5454566, createdName=ms1000001332061167, createdTime=Wed Jan 20 23:29:10 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918569, encodeId=411691856983, content=继续来学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Wed Jan 20 22:39:26 CST 2021, time=2021-01-20, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1778008, encodeId=75e41e7800850, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Fri Apr 30 19:32:48 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063390, encodeId=79452063390b6, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Sep 04 07:32:48 CST 2021, time=2021-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920414, encodeId=8db49204146f, content=怎么不来积分了。好奇怪, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01f52568974, createdName=1257c336m18暂无昵称, createdTime=Wed Jan 27 20:27:11 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298246, encodeId=ebc01298246a5, content=<a href='/topic/show?id=3379266918f' target=_blank style='color:#2F92EE;'>#体重增加#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26691, encryptionId=3379266918f, topicName=体重增加)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Fri Jan 22 13:32:48 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511906, encodeId=1fa715119067f, content=<a href='/topic/show?id=fd34100438e0' target=_blank style='color:#2F92EE;'>#颅咽管瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100438, encryptionId=fd34100438e0, topicName=颅咽管瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c66710405355, createdName=ms8435843352634314, createdTime=Fri Jan 22 13:32:48 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918861, encodeId=03ad91886102, content=进来学习一下了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Thu Jan 21 23:32:22 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918579, encodeId=62ad9185e9af, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acfe5454566, createdName=ms1000001332061167, createdTime=Wed Jan 20 23:29:10 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918569, encodeId=411691856983, content=继续来学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Wed Jan 20 22:39:26 CST 2021, time=2021-01-20, status=1, ipAttribution=)]
    2021-01-21 水-晶

    进来学习一下了

    0

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    2021-01-20 ms1000001332061167

    0

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    2021-01-20 水-晶

    继续来学习了

    0

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营养专家长期以来一直怀疑,过去50年来精加工食品的消耗增加是导致肥胖流行的主要原因。但是因为饮食习惯研究很复杂,难以直接关联。

Brit J Cancer:中年体重增加是肥胖相关癌症的危险因素!

由此可见,中年体重增加是一个很强的癌症危险因素。在那些同时患有代谢异常的患者中具有更强的风险。

Brit J Cancer:女性超重、体重增加与肥胖相关的癌症风险

由此可见,在中年维持稳定的体重,不论基线时的BMI如何,以及避免超重,对于预防女性几种与肥胖相关的癌症都很重要。研究人员首次发现了体重增加中等和较快的女性患胰腺癌的风险增加。

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