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日研究人员用转基因猪探究糖尿病及并发症

2017-05-31 佚名 健康报

日本研究人员日前利用转基因技术在猪身上再现了糖尿病及视网膜病和肾衰竭等并发症。在大型哺乳动物身上再现这些疾病,将有助于研究引起并发症的机制及相应的治疗方法。

日本研究人员日前利用转基因技术在猪身上再现了糖尿病及视网膜病和肾衰竭等并发症。在大型哺乳动物身上再现这些疾病,将有助于研究引起并发症的机制及相应的治疗方法。

据《日本经济新闻》5月29日报道,人体内可降低血糖值的胰岛素分泌不足会导致糖尿病。高血糖使血管和神经受损从而产生并发症,严重时会导致失明或肾衰竭等。

日本明治大学的一个研究小组利用最新的基因工程技术给猪转入了引发人类糖尿病的基因,使猪的胰岛素分泌减少并患上糖尿病。通过长期饲养观察发现,患病猪的血管也变得脆弱;视网膜出血症状不断加重,还出现了白内障;肾脏也出现了衰竭症状。

此前由于实验鼠的体重和寿命都和人类有较大差异,因此药物研发效果不如利用猪这类脏器大小和血糖值等与人类接近的哺乳动物。

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    2017-07-02 丁鹏鹏
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    2017-06-02 muzishouyi

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