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JACC:年轻人使用辅助生殖技术受孕,血管会持续老化 高血压风险将增加?

2018-10-12 王淳 环球医学

2018年9月,发表于《J Am Coll Cardiol》上的一项研究,考察了青春期辅助生殖技术(ART)与动脉高血压的相关性

2018年9月,发表于《J Am Coll Cardiol》上的一项研究,考察了青春期辅助生殖技术(ART)与动脉高血压的相关性

背景:ART已被证实可在表面健康的儿童中引起过早的血管老化。在小鼠中,ART诱导的过早血管老化能演变为动脉高血压。鉴于人类ART组的年龄较小,ART引起的心血管表型改变的长期后遗症尚不清楚。

目的:该研究假设血管改变持续存在于ART受孕的年轻人中,并且动脉高血压可能是该组中第一个可检测到的临床相关性终点。

方法:在初步评估5年后,研究人员重新对54名经ART受孕的表面年轻健康者和43名年龄、性别匹配的对照者进行血管功能评估和24小时动态血压(BP)监测(ABPM)。

结果:在ART受孕的参与者中,过早的血管老化持续存在,大约25%的血流介导的肱动脉扩张受损(p<0.001),脉速和颈动脉内膜中层厚度增加。最重要的是,ART受孕的参与者的ABPM值(收缩BP,119.8±9.1 mm Hg vs. 115.7±7.0 mm Hg,p=0.03;舒张BP,71.4±6.1 mm Hg vs. 69.1±4.2 mm Hg,p=0.02 ART vs.对照)和BP变化明显大于对照组。52名ART参与者中8名,但43名对照者中仅1名(ART vs对照组,p=0.041)符合ABPM动脉高血压标准(>130/80 mm Hg和/或>95%百分位数)。

结论:ART诱导的过早血管老化持续存在于表面健康的青少年和年轻成年人中,并且没有任何其他可以检测到的经典心血管风险因素,最后发展为动脉高血压。

原始出处:

Meister TA, Rimoldi SF, Soria R, et.al. Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence. J Am Coll Cardiol. 2018 Sep 11;72(11):1267-1274. doi: 10.1016/j.jacc.2018.06.060. 

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    2018-11-30 hbwxf
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    2019-07-24 楚秀娟
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