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Ann Surg:食管裂孔疝对食管或交界处腺癌术后的预后影响

2016-11-01 MedSci MedSci原创

评估食管裂孔疝(HH)≥5 厘米(HH组) vs 没有HH或HH<5 厘米(对照组)患者的肿瘤完整切除率(主要目的)、术后30天结局和生存(次要目标)。HH是食管或交界处腺癌(EGJA)的危险因素。EGJA术后HH对结局的影响仍是未知的。367例接受手术治疗的EGJA患者,通过CT和钡餐寻找HH,比较HH (n = 42)组和对照组(n = 325)。在HH组,EGJAs的不完全切除率更高(50.

评估食管裂孔疝(HH)≥5 厘米(HH组) vs 没有HH或HH<5 厘米(对照组)患者的肿瘤完整切除率(主要目的)、术后30天结局和生存(次要目标)。

HH是食管或交界处腺癌(EGJA)的危险因素。EGJA术后HH对结局的影响仍是未知的。

367例接受手术治疗的EGJA患者,通过CT和钡餐寻找HH,比较HH (n = 42)组和对照组(n = 325)。

在HH组,EGJAs的不完全切除率更高(50.0% vs 4.0%; P < 0.001),pN3期更多(28.5% vs 10.1%; P = 0.002),中位生存更低(20.9 vs 41.0个月; P = 0.001)。调整后,HH≥5 厘米是不完全切除(OR 21.0, 95% CI 9.4-46.8, P < 0.001)和不良预后(HR 1.6, 95% CI 1.1-2.5, P = 0.025)的预测因素。在HH组,接受新辅助放疗的患者,其30天死亡率明显更高(20.0% vs 0%; P = 0.040),这与更大的心脏和肺毒性有关。

这是第一次,我们发现,HH≥5 厘米与EGJA术后更差的预后有关,与更大的不完全切除率和更多的淋巴结受累有关,新辅助放疗对这类患者具有明显的毒性。

原始出处:

Gandon A1, Gronnier C,et al.Esophageal Adenocarcinoma: Impact of a Large Hiatal Hernia on Outcomes After Surgery.Ann Surg. 2016 Nov;264(5):862-870.

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    2016-11-03 zhouqu_8
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    2016-11-03 zwjnj2

    好好好学习了分享

    0

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    2016-11-01 drmike

    这个可以的~

    0

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