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DIABETOLOGIA:儿童体重指数和成人糖尿病的轨迹研究

2019-04-04 不详 网络

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本研究的目的是描述儿童体重指数的纵向分布,并研究独立水平的儿童体重指数对成人2糖尿病的影响。

纵向队列包括2449名成年人(1613名白人和836名黑人),从童年(4-19)到成年(20-51)对他们的BMI测量了415次,并在成年时测量了空腹血糖。采用生长曲线参数及其一阶导数,以1年为间隔计算儿童各年龄点BMI的模型估计水平和线性斜率。

结果显示,BMI从童年到成年符合立方生长曲线;不同种族、性别间的线性和非线性曲线参数差异显著。体重指数显示了15年后的种族和性别差异。在种族-性别组中,高血糖者的BMI水平高于正常血糖者。在成人高血糖组中,BMI的线性和非线性斜率参数始终存在显著差异。在对混杂因素进行校正后,4-19岁儿童的BMI水平的OR为成人高血糖1.45-1.83 (p < 0.001)10 ~ 19岁时BMI水平调整线性斜率与成人高血糖呈显著正相关(1.17 ~ 1.50,均p < 0.01)5 ~ 9岁儿童BMI线性斜率与成人高血糖的相关性不显著。这些关联的趋势在不同种族和性别群体中是一致的。

这些观察表明,儿童BMI轨迹对成人糖尿病有显著影响,与BMI水平无关。青春期是老年糖尿病发展的关键时期,对早期预防具有重要意义。

原始出处:

Tao ZhangJie Xu,Trajectories of childhood BMI and adult diabetes: the Bogalusa Heart Study

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2019-04-06 SCI我的梦

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    0

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    2019-04-05 misszhang

    谢谢MedSci提供最新的资讯

    0

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