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SCI REP:无症状性颈动脉疾病患者治疗策略的系统评价和荟萃分析!

2018-03-13 xing.T MedSci原创

由此可见,该网络荟萃分析结果表明就围手术期卒中风险和死亡率方面,BMT优于CEA和CAS。CEA是减少无症状颈动脉疾病患者同侧卒中和死亡长期风险的首选方法。

近日,Scientific reports杂志上发表了一篇研究文章,研究人员的目的是对无症状性颈动脉疾病的治疗策略进行系统回顾和荟萃分析。

研究人员检索了电子文献(Medline、Embase、CINAHL和CENTRAL等数据库)以确定报告了无症状的颈动脉疾病患者采用颈动脉内膜切除术(CEA)、颈动脉支架成形术(CAS)和最佳药物治疗(BMT)治疗比较结局的随机对照试验(RCT)。研究人员采用随机或固定效应模型进行两两配对的荟萃分析,并将结果报告为比值比(OR)或风险差(RD)以及95%可信区间(CI)。研究人员还进行了网络荟萃分析,并且使用了累计排名曲线下面积和平均排名得到了竞争干预的层次结构。30天内和随访期间卒中和死亡是主要的结局终点。

该荟萃分析共纳入了十一个随机对照试验,共包含了8954例患者。与BMT相比,CEA降低了受试者长期死亡率(OR为0.70,95%CI为0.43-1.12)和同侧卒中(OR为0.59,95%CI为0.50-0.71)的发生几率。

由此可见,该网络荟萃分析结果表明就围手术期卒中风险和死亡率方面,BMT优于CEA和CAS。CEA是减少无症状颈动脉疾病患者同侧卒中和死亡长期风险的首选方法。

原始出处:

Mohamed Barkat,et al. Systematic review and network meta-analysis of treatment strategies for asymptomatic carotid disease.Scientific reports.2018. https://www.nature.com/articles/s41598-018-22356-z

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2019-02-13 venlin
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    2018-03-15 huagfeg
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