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Br J Cancer:含糖饮料的摄入量影响结直肠癌患者的存活率

2021-07-19 xiaozeng MedSci原创

既往研究显示,

既往研究显示,能量的正向平衡与高胰岛素血症和结直肠癌(CRC)的发生发展存在着关联性。影响胰岛素水平的肥胖、缺乏身体活动和2型糖尿病是CRC发病的既定危险因素。然而,这些与代谢综合征和结直肠癌生存相关的风险因素的作用机制尚不清楚。

近期的研究表明,肥胖、缺乏运动、西方饮食模式(表现为大量摄入红肉和加工肉类、高脂乳制品和精制谷物)、高膳食血糖负荷和胰岛素评分均可能与CRC患者较差的生存期相关。


SSB(含糖饮料)是美国饮食中添加糖的最大来源,也是能量摄入的最大单一来源。SSB大多用高果糖玉米糖浆(通常为45%的葡萄糖和55%的果糖)或蔗糖增甜,后者是由半果糖和半葡萄糖组成。包括世界癌症研究基金会/美国癌症研究所等发布预防癌症的饮食建议里均包含了限制SSB和糖类的摄入量。然而,目前并不清楚高糖饮食对包括CRC在内的癌症患者存活率的影响。

该研究通过分析两项大型前瞻性队列研究:护士健康研究(NHS)和卫生专业人员随访研究(HPFS)的1463名I-III期CRC患者,研究患者在确诊后SSB、ASB(人工加糖饮料)、果汁、果糖和其他糖类的摄入量与CRC特异性和全因死亡率的风险比(HR)。


结果显示,在中位随访时间8.0年中,共有781例患者死亡(173例CRC特异性死亡)。研究人员发现,确诊后每天1份SSB或每天20克果糖的摄入与CRC特异性死亡率的多变量调整HR分别为1.21和1.24。CRC特异性死亡率的显著正相关主要在患者确诊后5年内观察到。进一步的研究显示,ASB与CRC特异性和全因死亡率之间呈显著负相关。

诊断后的随访时间与患者死亡率之间的关系

总而言之,该研究结果揭示,在疾病确诊后摄入更多的SSB和糖与患者更高的CRC特异性死亡率相关。而ASB与CRC特异性死亡率之间的负相关性则值得进一步的研究。


原始出处:

Zoltick, E.S., Smith-Warner, S.A., Yuan, C. et al. Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival. Br J Cancer (15 July 2021).

 

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    2022-01-09 lmm397
  2. [GetPortalCommentsPageByObjectIdResponse(id=1860709, encodeId=dd731860e0989, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Jan 09 02:03:27 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862993, encodeId=bee2186299343, content=<a href='/topic/show?id=b5ca453451f' target=_blank style='color:#2F92EE;'>#存活率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45345, encryptionId=b5ca453451f, topicName=存活率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Fri Apr 29 10:03:27 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1001334, encodeId=fbdf10013341f, content=所以说 含糖饮料 除了口感还行有什么好处呢?戒了吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210721/634efbe469ac4de4adbb705d254ecc73/40d470f00d2a4659bd6a9773e6ebdf18.jpg, createdBy=54092212914, createdName=天婧, createdTime=Wed Jul 21 09:18:07 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453549, encodeId=26c51453549dd, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Tue Jul 20 15:03:27 CST 2021, time=2021-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000800, encodeId=c2321000800fa, content=SSB(含糖饮料)是美国饮食中添加糖的最大来源,也是能量摄入的最大单一来源, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210603/b2c0b965f17441e0a3e3d3183c10efd2/ba96cdef43d448e0942789db93c3d589.jpg, createdBy=e9c15503371, createdName=KKsurvivor, createdTime=Mon Jul 19 10:01:49 CST 2021, time=2021-07-19, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1860709, encodeId=dd731860e0989, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Jan 09 02:03:27 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862993, encodeId=bee2186299343, content=<a href='/topic/show?id=b5ca453451f' target=_blank style='color:#2F92EE;'>#存活率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45345, encryptionId=b5ca453451f, topicName=存活率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Fri Apr 29 10:03:27 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1001334, encodeId=fbdf10013341f, content=所以说 含糖饮料 除了口感还行有什么好处呢?戒了吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210721/634efbe469ac4de4adbb705d254ecc73/40d470f00d2a4659bd6a9773e6ebdf18.jpg, createdBy=54092212914, createdName=天婧, createdTime=Wed Jul 21 09:18:07 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453549, encodeId=26c51453549dd, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Tue Jul 20 15:03:27 CST 2021, time=2021-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000800, encodeId=c2321000800fa, content=SSB(含糖饮料)是美国饮食中添加糖的最大来源,也是能量摄入的最大单一来源, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210603/b2c0b965f17441e0a3e3d3183c10efd2/ba96cdef43d448e0942789db93c3d589.jpg, createdBy=e9c15503371, createdName=KKsurvivor, createdTime=Mon Jul 19 10:01:49 CST 2021, time=2021-07-19, status=1, ipAttribution=)]
    2021-07-21 天婧

    所以说 含糖饮料 除了口感还行有什么好处呢?戒了吧

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1860709, encodeId=dd731860e0989, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Jan 09 02:03:27 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862993, encodeId=bee2186299343, content=<a href='/topic/show?id=b5ca453451f' target=_blank style='color:#2F92EE;'>#存活率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45345, encryptionId=b5ca453451f, topicName=存活率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Fri Apr 29 10:03:27 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1001334, encodeId=fbdf10013341f, content=所以说 含糖饮料 除了口感还行有什么好处呢?戒了吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210721/634efbe469ac4de4adbb705d254ecc73/40d470f00d2a4659bd6a9773e6ebdf18.jpg, createdBy=54092212914, createdName=天婧, createdTime=Wed Jul 21 09:18:07 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453549, encodeId=26c51453549dd, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Tue Jul 20 15:03:27 CST 2021, time=2021-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000800, encodeId=c2321000800fa, content=SSB(含糖饮料)是美国饮食中添加糖的最大来源,也是能量摄入的最大单一来源, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210603/b2c0b965f17441e0a3e3d3183c10efd2/ba96cdef43d448e0942789db93c3d589.jpg, createdBy=e9c15503371, createdName=KKsurvivor, createdTime=Mon Jul 19 10:01:49 CST 2021, time=2021-07-19, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1860709, encodeId=dd731860e0989, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Jan 09 02:03:27 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862993, encodeId=bee2186299343, content=<a href='/topic/show?id=b5ca453451f' target=_blank style='color:#2F92EE;'>#存活率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45345, encryptionId=b5ca453451f, topicName=存活率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Fri Apr 29 10:03:27 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1001334, encodeId=fbdf10013341f, content=所以说 含糖饮料 除了口感还行有什么好处呢?戒了吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210721/634efbe469ac4de4adbb705d254ecc73/40d470f00d2a4659bd6a9773e6ebdf18.jpg, createdBy=54092212914, createdName=天婧, createdTime=Wed Jul 21 09:18:07 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453549, encodeId=26c51453549dd, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Tue Jul 20 15:03:27 CST 2021, time=2021-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000800, encodeId=c2321000800fa, content=SSB(含糖饮料)是美国饮食中添加糖的最大来源,也是能量摄入的最大单一来源, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210603/b2c0b965f17441e0a3e3d3183c10efd2/ba96cdef43d448e0942789db93c3d589.jpg, createdBy=e9c15503371, createdName=KKsurvivor, createdTime=Mon Jul 19 10:01:49 CST 2021, time=2021-07-19, status=1, ipAttribution=)]
    2021-07-19 KKsurvivor

    SSB(含糖饮料)是美国饮食中添加糖的最大来源,也是能量摄入的最大单一来源

    0

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