发现一蛋白质可限制禽流感在哺乳动物中传播

2016-01-08 红枫科学报

图片来源：百度图片英国帝国理工学院的Wendy Barclay团队发现了一种能够限制甲型禽流感病毒在哺乳动物中复制的蛋白质，相关成果近日发表于《自然》杂志。鸟类是包括人类在内的很多动物的流感病毒来源。尽管科学家已经知道，大多数禽流感在没有获得特定变异时无法在人体中复制，但其背后机制尚不清楚。Barclay等人使用一组含有鸡基因组片段的仓鼠细胞系，研究了适应于禽类的蛋白如何在

图片来源：百度图片

英国帝国理工学院的Wendy Barclay团队发现了一种能够限制甲型禽流感病毒在哺乳动物中复制的蛋白质，相关成果近日发表于《自然》杂志。

鸟类是包括人类在内的很多动物的流感病毒来源。尽管科学家已经知道，大多数禽流感在没有获得特定变异时无法在人体中复制，但其背后机制尚不清楚。Barclay等人使用一组含有鸡基因组片段的仓鼠细胞系，研究了适应于禽类的蛋白如何在哺乳动物中运作。他们发现了一个单一蛋白ANP32A，限制了甲型禽流感病毒在哺乳动物中的运作。研究人员还发现蛋白PB2中有一个特定变异E627K，已知和禽流感病毒在哺乳动物中病毒性增强相关，而禽流感病毒必须获得E627K这个变异才能适应其宿主的蛋白质ANP32B。

美国亚特兰大埃默里大学Anice Lowen在同期的评论文章中表示：“现在尚不清楚甲型禽流感病毒是如何使用ANP32A的，阐明该蛋白在分子层面如何参与病毒复制可能给开发新的抗病毒药物开辟道路。”

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2016-01-18 柳叶一刀

#白质#

49 0
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2016-01-10 cmj8wellington

#蛋白质#

105 0
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2016-01-10 ms1065684921169360

#哺乳#

60 0
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2016-01-10 ms6279672939590805

#哺乳动物#

68 0

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