EHJ：骨髓源性细胞注射疗法可减少心肌梗死面积

2015-11-12 徐媛 MedSci原创

临床试验表明,在PCI术后1到7天内向冠脉内注射骨髓源性细胞可以改善左心室(LV)功能，但更早的时间点尚未评估。本文旨在确定PCI术后24小时内向冠脉内注射骨髓源性细胞治疗心梗的安全性。本研究进行了第二阶段多中心随机,双盲,安慰剂对照试验。研究纳入了100例既往急性心梗患者或存在明显局部室壁运动异常的患者，并按照1:1随机分配到术后接受骨髓源性细胞注射治疗以及对照组。主要终点是参与者1年时的左

临床试验表明,在PCI术后1到7天内向冠脉内注射骨髓源性细胞可以改善左心室(LV)功能，但更早的时间点尚未评估。本文旨在确定PCI术后24小时内向冠脉内注射骨髓源性细胞治疗心梗的安全性。

本研究进行了第二阶段多中心随机,双盲,安慰剂对照试验。研究纳入了100例既往急性心梗患者或存在明显局部室壁运动异常的患者，并按照1:1随机分配到术后接受骨髓源性细胞注射治疗以及对照组。主要终点是参与者1年时的左室射血分数变化。

1年时，与基线相比，尽管两组患者的LVEF都有所增加，但是群组间BMC差异很小(2.2%; 95% confidence interval, CI: -0.5 to 5.0; P = 0.10)。然而，术后接受骨髓源性细胞注射治疗组心肌挽救指数改善明显优于对照组(0.1%; 95% CI: 0.0-0.20; P = 0.048)。两组患者的不良反应事件发生率都很少。

以上研究结果表明:PCI术后24小时内向冠脉内注射骨髓源性细胞可减少梗死面积，而且在对急性心梗患者的心肌挽救（myocardial salvage）中起着重要的作用。

原始出处

Choudry F1, Hamshere S1, Saunders N2, Veerapen J1, Bavnbek K3, Knight C1, Pellerin D3, Locca D4, Westwood M1, Rakhit R5, Crake T3, Kastrup J6, Parmar M7, Agrawal S2, Jones D1, Martin J8, Mathur A9.A randomized double-blind control study of early intra-coronary autologous bone marrow cell infusion in acute myocardial infarction: the REGENERATE-AMI clinical trial†.Eur Heart J. 2015 Sep 23.

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2015-11-13 owlhealth

研究好，文章好

181 0
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2015-11-13 KO229256262

期待干细胞治疗

114 0
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2015-11-13 午夜星河

趋势好

153 0
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2015-11-12 sanshengshi

赞

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