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EBioMedicine:高脂食物可改变细胞生物钟

2016-04-07 QQduhp 译 MedSci原创

德州农工大学健康科学中心和德州农工大学生态农业研究所的的研究人员指出,在特定的时间段内进食高脂肪食物有可能改变机体生物钟,并引起炎症反应。研究结果发表在EBioMedicine。 全身细胞都有自己的生物钟。这些生物钟对调节细胞的新陈代谢等生理活动具有重要作用,对保障机体正常工作至关重要。此外,生物钟还有助于控制机体炎症反应。 然而,高脂肪饮食可导致慢性轻度炎症的出现,并增加民众患肥胖、2型糖尿病、

德州农工大学健康科学中心和德州农工大学生态农业研究所的的研究人员指出,在特定的时间段内进食高脂肪食物有可能改变机体生物钟,并引起炎症反应。研究结果发表在EBioMedicine。
 
全身细胞都有自己的生物钟。这些生物钟对调节细胞的新陈代谢等生理活动具有重要作用,对保障机体正常工作至关重要。此外,生物钟还有助于控制机体炎症反应。 

然而,高脂肪饮食可导致慢性轻度炎症的出现,并增加民众患肥胖、2型糖尿病、心血管疾病、卒中和风湿性关节炎的风险。David Earnest博士指出,摄入过量的脂肪会导致免疫细胞的生物钟减慢,降低免疫细胞正常工作的能力。 

Earnest教授和同事深入探究了棕榈酸盐(一种饱和脂肪酸)的效果。

Pubchem描述棕榈酸是一种含有16个碳分子的饱和长链脂肪酸。棕榈油、棕榈仁油、黄油、奶酪、牛奶和肉类等都富含棕榈酸。 

虽然人类可以轻易跨越不同的时区,但是由于他们是整个身体一起移动,因此有些细胞会自我调整而有些细胞不会,这时便会发生炎症。结果表明,棕榈酸盐可有效滞后细胞生物钟,并使得机体细胞改变各自的生物钟,并造成机体功能的紊乱,这样极易引起机体出现一系列代谢性疾病。博士指出,人们患慢性炎症的可能性取决于他们的进食种类。

他认为,吃高脂肪膳食的最佳时间是清晨,而最糟糕的时间可能是在深夜。并非所有的脂肪都是坏的。 事实上,当摄入太多饱和脂肪酸食物导致机体出现炎症反应及细胞生物钟紊乱后,某些对人体有益的不饱和脂肪酸和抗炎药可以将生物钟调整至最初状态。
 
ω- 3脂肪酸或其他抗炎治疗方法可以用来摄入太多饱和脂肪酸导致机体细胞的生物钟紊乱。研究人员指出,我们可以对机体某些特定组织控制炎症反应,帮助机体修复感染或损伤。 
  
原始出处:
Sam-Moon Kima,Nichole Neuendorffc,Robert S.Chapkind,David J. Earnest.Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.EBioMedicine.doi:10.1016/j.ebiom.2016.03.037

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    2017-01-14 kalseyzl
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    2016-11-22 linagood
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  4. 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createdName=linagood, createdTime=Tue Nov 22 14:59:00 CST 2016, time=2016-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749232, encodeId=41f11e492329a, content=<a href='/topic/show?id=15ece796246' target=_blank style='color:#2F92EE;'>#细胞生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77962, encryptionId=15ece796246, topicName=细胞生物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eedf36252858, createdName=wetgdt, createdTime=Sat Oct 29 21:59:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917261, encodeId=9d37191e2613a, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, 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topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Fri Feb 24 22:59:00 CST 2017, time=2017-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416704, encodeId=aab81416e0437, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Fri Apr 08 23:59:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574560, encodeId=098515e4560bf, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, 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href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Apr 08 23:59:00 CST 2016, time=2016-04-08, status=1, ipAttribution=)]
    2016-08-24 sunylz
  5. [GetPortalCommentsPageByObjectIdResponse(id=1773543, encodeId=656e1e7354324, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Sat Jan 14 13:59:00 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997080, encodeId=91bb199e080e1, content=<a href='/topic/show?id=9221645e6f' target=_blank style='color:#2F92EE;'>#EBI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6457, encryptionId=9221645e6f, topicName=EBI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, 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topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Fri Feb 24 22:59:00 CST 2017, time=2017-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416704, encodeId=aab81416e0437, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Fri Apr 08 23:59:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574560, encodeId=098515e4560bf, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, 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href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Apr 08 23:59:00 CST 2016, time=2016-04-08, status=1, ipAttribution=)]
    2016-05-07 1dd8c52fm63(暂无匿称)

    不吃肉生活没有乐趣!

    0

  6. 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encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Aug 24 20:59:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84522, encodeId=5999845224d, content=不吃肉生活没有乐趣!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat May 07 16:52:00 CST 2016, time=2016-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858671, encodeId=3bcb18586e17b, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Fri Feb 24 22:59:00 CST 2017, time=2017-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416704, encodeId=aab81416e0437, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Fri Apr 08 23:59:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574560, encodeId=098515e4560bf, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, 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href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Apr 08 23:59:00 CST 2016, time=2016-04-08, status=1, ipAttribution=)]
    2017-02-24 jeanqiuqiu
  7. 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    2016-04-08 yhy100201
  8. 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    2016-04-08 pcw111
  9. 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