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新的生物标志物在孕妇妊娠六周时便可预测其先兆子痫的发生

2015-11-21 MedSci MedSci原创

新的生物标志物在孕妇妊娠六周时便可预测其先兆子痫的发生先兆子痫一般是在孕妇妊娠后期才可诊断,但是新的研究表明,先兆子痫在孕妇妊娠的前三个月便可诊断,并可因此促进新的预防措施的发展。

先兆子痫一般是在孕妇妊娠后期才可诊断,但是新的研究表明,先兆子痫在孕妇妊娠的前三个月便可诊断,并可因此促进新的预防措施的发展。

先兆子痫是以孕期高血压和高水平的蛋白尿为特征,可导致孕妇及其胎儿发生严重的并发症,包括导致胎儿宫内生长迟缓;孕妇癫痫发作、中风或多器官衰竭;孕妇或胎儿死亡。通常,唯一的治疗方法便是提早分娩胎儿。近日发表于Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender的一项新的研究表明,copeptin蛋白可在孕妇怀孕六周时预测先兆子痫的发生。

首席研究员Mark Santillan博士说道,该研究的发现意义重大,因为早期识别处于先兆子痫发生高风险中的孕妇可使得医疗保健提供者迅速对此作出反应并可为孕妇提供适当的护理。“临床上,六周这个时间段已经是可检测出孕妇先兆子痫的最短妊娠时间。通过copeptin便可预测孕妇先兆子痫的发生。”

copeptin是精氨酸加压素(AVP)蛋白的一个副产物。研究还发现,整个妊娠期间给予妊娠小鼠AVP后,小鼠可出现人类子痫前期所出现的所有的心血管、肾脏、产科以及免疫成分。

此两项研究发现表明,AVP参与了先兆子痫的发生。因此靶向此通路或可治疗,预防,甚至是治愈先兆子痫。

原始出处:

New biomarker predicts development of preeclampsia at six weeks of pregnancy. Science Daily, November 20, 2015.


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    2017-05-10 laymankey

    感谢分享一下!

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