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JAHA:美式足球运动员高血压和心室-动脉解偶联的患病情况

2022-02-26 MedSci原创 MedSci原创

VA解偶联与大学美式足球运动员的SBP病理性增加和左心室收缩功能的亚临床损伤相关,是该人群中观察到的不良心血管疾病表型的关键机制。未来的研究有必要分析针对性的临床干预是否可以改善VA耦合和健康结局。

心室-动脉(VA)耦合定义为动脉弹性(EA)与左心室弹性(ELV)之间的比率。VA解偶联,如发生在高血压性心脏病中,与患者不良结局相关。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在明确美式足球相关高血压与VA解偶联之间的关系。

这是一项针对参与3年美式足球运动的大学美式足球运动员进行的多中心、纵向和重复测量的观察性研究。在最初注册的200名新生运动员中,142名(67名黑人[47%]/75名白人[53%],58名前锋[41%]/84名非前锋[59%])接受了超声心动图和压平眼压计检查。该研究的主要超声心动图VA耦合结果指标包括EA/ELV和ΔEA/ELV,其中EA/ELV增加表明VA解耦。

调整种族和球员位置后,美式足球运动员的EA/ELV(平均[95%CI]Δ为0.10[0.04-0.15];P=0.001)和收缩压(SBP)(平均[95%CI]Δ为11.4[8.3-14.5]mmHg,P<0.001)在他们的大学美式足球运动生涯中逐渐增加。结合纵向VA解偶联,高血压患病率(包括1期和2期高血压)从基线时的54%增加到研究期结束时的77%(2期高血压为44%)(P<0.001)。在多变量混合效应线性回归分析中,较高的SBP(β=0.021,P=0.02)、较低的E'(β=-0.010,P=0.03)和较差的整体纵向应变(β=0.036,P<0.001)与更高的EA/ELV相关。SBP增加(ΔSBP,β=0.029,P=0.02)和整体纵向应变恶化(Δ整体纵向应变,β=0.045,P<0.001)也预测ΔEA/ELV的增加。

由此可见,VA解偶联与大学美式足球运动员的SBP病理性增加和左心室收缩功能的亚临床损伤相关,是该人群中观察到的不良心血管疾病表型的关键机制。未来的研究有必要分析针对性的临床干预是否可以改善VA耦合和健康结局。

原始出处:

Jason V. Tso.et al.Hypertension and Ventricular–Arterial Uncoupling in Collegiate American Football Athletes.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.023430

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    2022-02-27 zhaohui6731
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    2022-02-27 gujh
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    2022-02-26 一个还在学习的医学生

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1765176, encodeId=4bc91e65176c4, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Jul 28 22:31:52 CST 2022, time=2022-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268773, encodeId=f8091268e7352, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Feb 27 14:31:52 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604615, encodeId=326a160461520, content=<a href='/topic/show?id=88e6941544c' target=_blank style='color:#2F92EE;'>#运动员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94154, encryptionId=88e6941544c, topicName=运动员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c1419230799, createdName=gujh, createdTime=Sun Feb 27 14:31:52 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197636, encodeId=85f7119e6360e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5e1963889, createdName=一个还在学习的医学生, createdTime=Sat Feb 26 23:13:29 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197590, encodeId=f817119e5900a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=296a6497387, createdName=ms2000001939126778, createdTime=Sat Feb 26 21:29:43 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197535, encodeId=24b5119e53591, content=文章很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79f56455521, createdName=ms5000000520551871, createdTime=Sat Feb 26 17:22:27 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197530, encodeId=c3d2119e5303e, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82d31990773, createdName=robbert123, createdTime=Sat Feb 26 16:59:40 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197520, encodeId=9d78119e52073, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Feb 26 16:35:18 CST 2022, time=2022-02-26, status=1, ipAttribution=)]
    2022-02-26 ms2000001939126778

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1765176, encodeId=4bc91e65176c4, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Jul 28 22:31:52 CST 2022, time=2022-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268773, encodeId=f8091268e7352, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Feb 27 14:31:52 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604615, encodeId=326a160461520, content=<a href='/topic/show?id=88e6941544c' target=_blank style='color:#2F92EE;'>#运动员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94154, encryptionId=88e6941544c, topicName=运动员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c1419230799, createdName=gujh, createdTime=Sun Feb 27 14:31:52 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197636, encodeId=85f7119e6360e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5e1963889, createdName=一个还在学习的医学生, createdTime=Sat Feb 26 23:13:29 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197590, encodeId=f817119e5900a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=296a6497387, createdName=ms2000001939126778, createdTime=Sat Feb 26 21:29:43 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197535, encodeId=24b5119e53591, content=文章很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79f56455521, createdName=ms5000000520551871, createdTime=Sat Feb 26 17:22:27 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197530, encodeId=c3d2119e5303e, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82d31990773, createdName=robbert123, createdTime=Sat Feb 26 16:59:40 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197520, encodeId=9d78119e52073, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Feb 26 16:35:18 CST 2022, time=2022-02-26, status=1, ipAttribution=)]
    2022-02-26 ms5000000520551871

    文章很实用

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1765176, encodeId=4bc91e65176c4, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Jul 28 22:31:52 CST 2022, time=2022-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268773, encodeId=f8091268e7352, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Feb 27 14:31:52 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604615, encodeId=326a160461520, content=<a href='/topic/show?id=88e6941544c' target=_blank style='color:#2F92EE;'>#运动员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94154, encryptionId=88e6941544c, topicName=运动员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c1419230799, createdName=gujh, createdTime=Sun Feb 27 14:31:52 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197636, encodeId=85f7119e6360e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5e1963889, createdName=一个还在学习的医学生, createdTime=Sat Feb 26 23:13:29 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197590, encodeId=f817119e5900a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=296a6497387, createdName=ms2000001939126778, createdTime=Sat Feb 26 21:29:43 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197535, encodeId=24b5119e53591, content=文章很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79f56455521, createdName=ms5000000520551871, createdTime=Sat Feb 26 17:22:27 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197530, encodeId=c3d2119e5303e, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82d31990773, createdName=robbert123, createdTime=Sat Feb 26 16:59:40 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197520, encodeId=9d78119e52073, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Feb 26 16:35:18 CST 2022, time=2022-02-26, status=1, ipAttribution=)]
    2022-02-26 robbert123

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1765176, encodeId=4bc91e65176c4, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Jul 28 22:31:52 CST 2022, time=2022-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268773, encodeId=f8091268e7352, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Feb 27 14:31:52 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604615, encodeId=326a160461520, content=<a href='/topic/show?id=88e6941544c' target=_blank style='color:#2F92EE;'>#运动员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94154, encryptionId=88e6941544c, topicName=运动员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c1419230799, createdName=gujh, createdTime=Sun Feb 27 14:31:52 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197636, encodeId=85f7119e6360e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5e1963889, createdName=一个还在学习的医学生, createdTime=Sat Feb 26 23:13:29 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197590, encodeId=f817119e5900a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=296a6497387, createdName=ms2000001939126778, createdTime=Sat Feb 26 21:29:43 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197535, encodeId=24b5119e53591, content=文章很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79f56455521, createdName=ms5000000520551871, createdTime=Sat Feb 26 17:22:27 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197530, encodeId=c3d2119e5303e, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82d31990773, createdName=robbert123, createdTime=Sat Feb 26 16:59:40 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1197520, encodeId=9d78119e52073, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Feb 26 16:35:18 CST 2022, time=2022-02-26, status=1, ipAttribution=)]
    2022-02-26 医鸣惊人

    认真学习了

    0

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