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挪威的肾脏捐赠者与普通人群的整体及心血管死亡率的比较

2012-04-10 范振光 肾脏病与透析肾移植

    此研究纳入挪威1963至2007年期间所有的活体肾脏捐赠者。对照组是由挪威统计局提供的普通人群,并按3:1的比例对年龄、性别、出生年月进行匹配,死亡原因均来源于死亡主文件,观察终点至2010年1月1日,死亡终点截止至2008年1月1日,用 Kaplan-Meier曲线和log-rank检验比较生存分析,对分层年龄的死亡率进行了计算,并与假设愿意捐赠的健康人群比较。 &

    此研究纳入挪威1963至2007年期间所有的活体肾脏捐赠者。对照组是由挪威统计局提供的普通人群,并按3:1的比例对年龄、性别、出生年月进行匹配,死亡原因均来源于死亡主文件,观察终点至2010年1月1日,死亡终点截止至2008年1月1日,用 Kaplan-Meier曲线和log-rank检验比较生存分析,对分层年龄的死亡率进行了计算,并与假设愿意捐赠的健康人群比较。       结果,共有2269肾脏捐赠者纳入研究。 在捐赠组中,平均年龄为47.6±12.6岁,其中41.3%为男性。 观测时间中位数为14.3年。 在研究期间,共有324个捐赠者死亡。捐赠组与对照组的死亡原因类似。 通过Kaplan-Meier分析,捐赠组整体和心血管疾病的死亡率明显低于对照组,更明显低于早期的捐赠者(P = 0.004和P <0.001)。年龄分层分析表明越早的捐赠者的死亡率越高。       结论:捐赠者整体和心血管疾病的死亡率结果令人欣慰。 然而,越早期的捐赠者死亡率升高,需要进一步研究。
文献地址: http://www.medlive.cn/literature/32165 

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