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PloS Med:控制HIV大流行:全球进展报告

2017-05-04 Heather_z727 来宝网

公共科学图书馆·医学》杂志上发表临床试验干预管理实现全球艾滋病测试和治疗的评估,此次研究由英国伦敦卫生与热带医学学院的研究人员们发起。

《公共科学图书馆·医学》杂志上发表临床试验干预管理实现全球艾滋病测试和治疗的评估,此次研究由英国伦敦卫生与热带医学学院的研究人员们发起。



研究地点为赞比亚,通过干预管理一年之后,得知自己患有HIV的人数从之前的52%,上升到78%;接受抗逆转录病毒治疗的比例也从之前的44%,上升到66%。虽然HIV的治疗和预防都在不断进步中,然而2015年,新感染HIV的人数还是达到了210万人,在中低收入国家,有超过100万人死于艾滋病感染。为了改善这一现状,联合国艾滋病规划署制定了3个90计划,即得知自己患有艾滋病的比例达到90%,接受抗逆转录病毒治疗的比例达到90%,持续进行病毒抑制的人数达到90%。

此次计划已在赞比亚和南非多个国家开始实施。研究人员把测试仪器带入每个家庭,为他们提供艾滋病测试和咨询,并对艾滋病感染者,肺结核患者以及其他慢性疾病患者进行后续的医疗保健,通过此次干预管理,人们的艾滋病意识明显提高,得知自己患病的人数,以及患病后开始接受治疗和措施的人数也在不断攀升中。然而研究还表明,此次研究在年轻人中的覆盖率较低,进一步的后续干预还在进行中。

研究人员总结道:“总的来说,我们不可能在一朝一夕之间就完全控制这一困扰全球的流行病,但是通过最适当的资源调配,相信在不远的将来,HIV将不再是威胁。”

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    2017-05-11 杨利洪

    好好学习,洁身自爱

    0

  2. 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    2017-05-08 惠映实验室

    时刻要关注的热点

    0

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  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri May 05 10:24:33 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193875, encodeId=ed341938e5aa, content=希望尽快控制ARDS, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Fri May 05 00:19:15 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193660, encodeId=f0e419366033, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu May 04 05:54:01 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-05 虈亣靌

    继续学习中谢谢

    0

  5. 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content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu May 04 05:54:01 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-05 ren1mw

    希望尽快控制ARDS

    0

  6. 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channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu May 04 07:43:19 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193563, encodeId=bfb219356315, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Thu May 04 07:27:58 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193483, encodeId=99d619348393, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu May 04 05:54:01 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 137****4081

    0

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content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu May 04 05:54:01 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 医艺依意

    科学防艾,健康你我

    0

  8. 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channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu May 04 07:43:19 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193563, encodeId=bfb219356315, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Thu May 04 07:27:58 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193483, encodeId=99d619348393, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu May 04 05:54:01 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 flysky120

    减少艾滋病的发生,艾滋病的提前预防还是重要。

    0

  9. 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channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu May 04 07:43:19 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193563, encodeId=bfb219356315, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Thu May 04 07:27:58 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193483, encodeId=99d619348393, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu May 04 05:54:01 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 1dd8aa01m06(暂无匿称)

    学习了很好的内容

    0

  10. 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channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu May 04 07:43:19 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193563, encodeId=bfb219356315, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Thu May 04 07:27:58 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193483, encodeId=99d619348393, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu May 04 05:54:01 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 刘煜

    学习了,谢谢分享。

    0

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这项研究是为了评估感染HIV的美国退伍军人罹患与HIV或其他临床病症相关的口咽癌(OPSCC)的危险因素。

Mol Ther:研究显示切除HIV-DNA或将实现永久治愈艾滋病!

艾滋病毒感染的永久治疗仍然难以捉摸,因为病毒能够隐藏在潜伏的储库中。但是现在,在5月3日刊登在“分子治疗”杂志的新研究中,Temple University(LKSOM)和匹兹堡大学的Lewis Katz医学院的科学家表明,他们可以从活体基因组中切除HIV DNA消除进一步的感染。他们是第一个在三种不同的动物模型中进行试验的,包括一种“人性化”模式,其中小鼠被移植人免疫细胞,并感染病毒。

CELL HOST MICROBE:这种前体病毒竟是导致HIV不能治愈的幕后黑手!

约翰霍普金斯大学和乔治华盛顿大学的研究人员报告了新的证据,证明由之前被认为无害的缺陷型HIV形成的蛋白质,实际上与我们的免疫系统相互作用,并被特定类型的免疫细胞(称为细胞毒性T细胞)主动监测。

PLOS PATHOG:找到HIV“顽固存在”的根源,或能将其斩草除根

在HIV的治疗领域,长久以来一直有着引起医学界争论的问题,究竟是长期接受抗逆转录病毒(ART)治疗患者体内的微量HIV引起了炎症并激活了免疫系统,还是炎症和激活的免疫系统导致了ART治疗期间患者体内依然存在微量HIV病毒?

Nature:研究发现HIV“久攻不下”的原因,攻克HIV的关键点浮出水面!

【研究人员发现新的艾滋病毒储库】迄今为止的艾滋病毒治疗研究集中在清除来自T细胞——组成免疫系统的一种重要白细胞,的病毒。然而北卡罗来纳大学医学院传染病科的调查人员发现病毒持续存在于HIV感染的巨噬细胞中。巨噬细胞是在包括肝,肺,骨髓和脑在内的全身组织中发现的大白细胞。这种附加病毒储库的发现对艾滋病毒治疗研究具有重要意义。这些发现于4月17日星期一在Nature Medicine发表。 “

Nature Medicine:抗逆转录病毒治疗期间组织巨噬细胞中HIV持续存在!

这些观察结果表明这是第一个直接的证据证实在体内组织巨噬细胞存在HIV持续感染。

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