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Int J Nanomed：新型空心碳球化疗药物载体可更好的治疗食管癌

2017-10-10 MedSci MedSci原创

空心碳球化疗药物食管癌
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低毒性和高效率是影响纳米材料辅助药物递送在现实临床应用的关键因素。在这项研究中，研究人员研发了尺寸分布较窄的新型空心碳球（HCSs）。除了证明其易于合成以大规模生产之外，研究人员还在体外证明了HCSs在低pH下具有较高的药物负载能力，较低的细胞毒性和最佳的药物释放特征，与肿瘤微环境中的pH相似。此外，HCSs还显示出优异的免疫相容性，并且可在细胞质中快速分散开来以逃脱溶酶体的清除。更重要的是，HC

低毒性和高效率是影响纳米材料辅助药物递送在现实临床应用的关键因素。

在这项研究中，研究人员研发了尺寸分布较窄的新型空心碳球（HCSs）。除了证明其易于合成以大规模生产之外，研究人员还在体外证明了HCSs在低pH下具有较高的药物负载能力，较低的细胞毒性和最佳的药物释放特征，与肿瘤微环境中的pH相似。

此外，HCSs还显示出优异的免疫相容性，并且可在细胞质中快速分散开来以逃脱溶酶体的清除。更重要的是，HCSs可以有效地将多柔比星（具有代表性的化疗药物）输送到肿瘤部位，从而可明显抑制食管异种移植癌模型中肿瘤的生长。这也延长了药物在血循环中的存在时间，改变了药物的生物分布。

总之，这项研究揭示了一种靶向肿瘤治疗的新型药物输送系统。

原始出处：

Li Zhang,Mengchu Yao, et al., Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment. Int J Nanomedicine. 2017; 12: 6759–6769. doi:  10.2147/IJN.S142916

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    2018-09-19 mei539

    #载体#

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    2017-10-12 luwei03

    #化疗药物#

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    2017-10-12 智慧医人

    #Med#

    0

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