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Arch Gynecol Obstet：妊娠剧吐对孕妇和胎儿的影响研究

2015-03-20 MedSci 译 MedSci原创

妊娠剧吐甲状腺激素恶性呕吐
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<span style="mso-bookmark: OLE_LINK7"><span style="font-size:11.0pt; font-weight:normal;mso-bidi-font-weight:bold">妊娠剧吐是发生于妊娠早期至妊娠16周之间、以恶心呕吐频繁为重要症状的一组症候群，发病率为0.3%-1%。恶性呕吐者可因酸中毒、电解质紊

妊娠剧吐是发生于妊娠早期至妊娠16周之间、以恶心呕吐频繁为重要症状的一组症候群，发病率为0.3%-1%。恶性呕吐者可因酸中毒、电解质紊乱、肝肾衰竭而死亡。


Buyukkayaci Duman N等人对妊娠剧吐孕妇进行了一项病例对照试验，以探究妊娠剧吐对孕产妇和胎儿/新生儿的影响。该研究共纳入了100名孕妇，其中50名为正常妊娠孕妇，50名为妊娠剧吐孕妇。研究者们收集孕妇的相关人口统计学资料、妊娠并发症、新生儿健康情况等数据。对孕产妇进行了贝克抑郁问卷（BDI）和状态焦虑问卷（SAI）。同时记录了孕妇血常规、甲功、电解质、生化等检查结果数据。

研究结果显示，妊娠剧吐孕妇在产后其平均体重、血清血红蛋白水平、血细胞压积、促甲状腺激素均低于正常组，p<0.01。但是妊娠剧吐组其三碘甲状腺原氨酸（T3）、甲状腺素（T4）比正常组高，p<0.01。妊娠剧吐组和正常组在胎儿宫内生长受限、低体重儿、流产三方面相比差别无统计学意义。妊娠剧吐组早产儿发生率更高。妊娠剧吐组孕产妇BDI和SAI得分更高。

研究结果表明，妊娠剧吐对孕产妇和胎儿均有一定的不良影响。因此对妊娠剧吐孕妇，应该提供训练有素、可供咨询的服务，同时建议根据贫血、甲状腺激素等情况，对孕妇进行严密监测。

原始出处：
Buyukkayaci Duman N, Ozcan O, Bostanci MÖ.Hyperemesis gravidarum affects maternal sanity, thyroid hormones and fetal health: a prospective case control study. Arch Gynecol Obstet. 2015 Feb 1

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1634466, encodeId=63e1163446667, content=<a href='/topic/show?id=1c5544842cd' target=_blank style='color:#2F92EE;'>#妊娠剧吐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44842, encryptionId=1c5544842cd, topicName=妊娠剧吐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2fd022178436, createdName=paperyu, createdTime=Wed Mar 02 23:38:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043846, encodeId=47812043846f4, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat May 02 11:38:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19222, encodeId=73bb19222a0, content=提醒很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:29:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011184, encodeId=385c201118423, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Sat Jul 25 17:38:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18627, encodeId=7ad11862e38, content=需要干预, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sun Mar 22 09:29:00 CST 2015, time=2015-03-22, status=1, ipAttribution=)]
    2016-03-02 paperyu

    #妊娠剧吐#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1634466, encodeId=63e1163446667, content=<a href='/topic/show?id=1c5544842cd' target=_blank style='color:#2F92EE;'>#妊娠剧吐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44842, encryptionId=1c5544842cd, topicName=妊娠剧吐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2fd022178436, createdName=paperyu, createdTime=Wed Mar 02 23:38:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043846, encodeId=47812043846f4, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat May 02 11:38:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19222, encodeId=73bb19222a0, content=提醒很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:29:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011184, encodeId=385c201118423, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Sat Jul 25 17:38:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18627, encodeId=7ad11862e38, content=需要干预, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sun Mar 22 09:29:00 CST 2015, time=2015-03-22, status=1, ipAttribution=)]
    2015-05-02 1249842em09(暂无昵称)

    #NEC#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1634466, encodeId=63e1163446667, content=<a href='/topic/show?id=1c5544842cd' target=_blank style='color:#2F92EE;'>#妊娠剧吐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44842, encryptionId=1c5544842cd, topicName=妊娠剧吐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2fd022178436, createdName=paperyu, createdTime=Wed Mar 02 23:38:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043846, encodeId=47812043846f4, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat May 02 11:38:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19222, encodeId=73bb19222a0, content=提醒很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:29:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011184, encodeId=385c201118423, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Sat Jul 25 17:38:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18627, encodeId=7ad11862e38, content=需要干预, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sun Mar 22 09:29:00 CST 2015, time=2015-03-22, status=1, ipAttribution=)]
    2015-03-31 x35042875

    提醒很重要

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1634466, encodeId=63e1163446667, content=<a href='/topic/show?id=1c5544842cd' target=_blank style='color:#2F92EE;'>#妊娠剧吐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44842, encryptionId=1c5544842cd, topicName=妊娠剧吐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2fd022178436, createdName=paperyu, createdTime=Wed Mar 02 23:38:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043846, encodeId=47812043846f4, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat May 02 11:38:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19222, encodeId=73bb19222a0, content=提醒很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:29:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011184, encodeId=385c201118423, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Sat Jul 25 17:38:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18627, encodeId=7ad11862e38, content=需要干预, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sun Mar 22 09:29:00 CST 2015, time=2015-03-22, status=1, ipAttribution=)]
    2015-07-25 yhy100200

    #TET#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1634466, encodeId=63e1163446667, content=<a href='/topic/show?id=1c5544842cd' target=_blank style='color:#2F92EE;'>#妊娠剧吐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44842, encryptionId=1c5544842cd, topicName=妊娠剧吐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2fd022178436, createdName=paperyu, createdTime=Wed Mar 02 23:38:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043846, encodeId=47812043846f4, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat May 02 11:38:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19222, encodeId=73bb19222a0, content=提醒很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:29:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011184, encodeId=385c201118423, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Sat Jul 25 17:38:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18627, encodeId=7ad11862e38, content=需要干预, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sun Mar 22 09:29:00 CST 2015, time=2015-03-22, status=1, ipAttribution=)]
    2015-03-22 xiaoai5777

    需要干预

    0

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