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Ann Rheum Dis:痛风患者不易患阿尔茨海默氏症?

2015-04-20 徐媛媛译 MedSci原创

抗氧化剂尿酸可能对神经有保护作用,然而痛风与心血管(CV)代谢并发症和后遗症相关。本文比较了痛风患者阿尔茨海默氏症(AD)发病率。 本文进行了一项年龄,性别,体重指数(BMI)进行配对的数据队列研究,数据来源于1995年1月1日到2013年12月31日的The Health Improvement Network,英国人口电子病历数据库。我们比较了在痛风和队列组间(不包括基线时痛风患者或痴呆)阿

抗氧化剂尿酸可能对神经有保护作用,然而痛风与心血管(CV)代谢并发症和后遗症相关。本文比较了痛风患者阿尔茨海默氏症(AD)发病率。

本文进行了一项年龄,性别,体重指数(BMI)进行配对的数据队列研究,数据来源于1995年1月1日到2013年12月31日的The Health Improvement Network,英国人口电子病历数据库。我们比较了在痛风和队列组间(不包括基线时痛风患者或痴呆)阿尔茨海默氏症(AD)的发病率。计算多变量危险比(HRs)同时调整吸烟、饮酒、就诊、社会剥夺指数、并发症发生以及药物使用情况。我们在新发骨关节炎(OA)患者中做了相同的分析作为阴性对照。

在超过5年的随访期间,我们收纳的59224例痛风患者(女性占29%,平均年龄65岁)中新增阿尔茨海默病(AD)患者309例以及238805名对照组中新增AD患者1942例,患病率分别为1.0/1000人年和1.5/1000人年。单变量(年龄、性别和体重指数)和多变量危险比(HRs)在AD危险比分别为为0.71(95% CI 0.62 - 0.80)和0.76(95% CI 0.66 - 0.87)。在依据性别、年龄组(<75和≥75岁)、社会剥夺指数和心血管病史分层的亚组患者中,仍存在负相关。新发OA与阿尔茨海默氏症AD风险无相关性。

研究结果发现痛风与患阿尔茨海默病(AD)风险呈负相关,抗氧化剂尿酸可能对神经有保护作用。

原始出处

Lu N1, Dubreuil M2, Zhang Y3, Neogi T3, Rai SK4, Ascherio A5, Hernán MA5, Choi HK6.Gout and the risk of Alzheimer's disease: a population-based, BMI-matched cohort study.Ann Rheum Dis. 2015 Mar 4.

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    2016-03-14 忠诚向上

    好好学习,继续研究

    0

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    2016-03-14 忠诚向上

    好好学习,继续研究

    0

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    2016-03-14 忠诚向上

    好好学习,继续研究

    0

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    2016-03-14 忠诚向上

    好好学习,继续研究

    0

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    2016-03-14 忠诚向上

    好好学习,继续研究

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=68928, encodeId=9c3a6892836, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68929, encodeId=8f2a68929b4, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68930, encodeId=69536893005, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68931, encodeId=34a86893171, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68932, encodeId=52d668932c3, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68933, encodeId=76e868933b2, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68934, encodeId=5d3a6893481, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68935, encodeId=197168935ec, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817665, encodeId=1586181e6655a, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Wed Mar 30 06:29:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011973, encodeId=19f120119e383, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Sep 23 09:29:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
    2016-03-14 忠诚向上

    好好学习,继续研究

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=68928, encodeId=9c3a6892836, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68929, encodeId=8f2a68929b4, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68930, encodeId=69536893005, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68931, encodeId=34a86893171, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68932, encodeId=52d668932c3, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68933, encodeId=76e868933b2, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68934, encodeId=5d3a6893481, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68935, encodeId=197168935ec, content=好好学习,继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 14 07:51:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817665, encodeId=1586181e6655a, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Wed Mar 30 06:29:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011973, encodeId=19f120119e383, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Sep 23 09:29:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
    2016-03-14 忠诚向上

    好好学习,继续研究

    0

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    2016-03-14 忠诚向上

    好好学习,继续研究

    0

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