Stem Cell Rep：科学家成功将胚胎干细胞转化成为甲状腺细胞

2017-02-04 生物谷生物谷

近日，一项刊登于国际杂志Stem Cell Reports上的研究报告中，来自波士顿大学医学院的研究人员通过研究，成功利用遗传修饰化的胚胎干细胞再生出了甲状腺细胞，同时研究人员也首次利用基于人类干细胞的相似步骤来更好地模拟甲状腺疾病来更好地理解甲状腺疾病的发病原因，并未开发新型疗法提供一

图片来源：www.sciencedaily.com

近日，一项刊登于国际杂志Stem Cell Reports上的研究报告中，来自波士顿大学医学院的研究人员通过研究，成功利用遗传修饰化的胚胎干细胞再生出了甲状腺细胞，同时研究人员也首次利用基于人类干细胞的相似步骤来更好地模拟甲状腺疾病来更好地理解甲状腺疾病的发病原因，并未开发新型疗法提供一定思路。

在美国，甲状腺疾病影响着大约10%的人群健康，甲状腺疾病包括格雷夫斯氏病和桥本病，其会导致甲亢或甲状腺功能减退、甲状腺结节、甲状腺肿或癌症发生。

研究人员对实验室中培养的小鼠胚胎干细胞进行工程化操作使其能够表达一种特殊基因：Nkx2-1，该基因对于甲状腺发育非常重要，随后当研究人员短暂开启/关闭Nkx2-1基因时，他们通过多个步骤来指导胚胎干细胞，结果发现，在一个非常狭窄的时间范围内，开启Nkx2-1的表达就能够将大部分胚胎干细胞转化成为甲状腺细胞。

Laertis Ikonomou博士指出，这种新方法能够帮助我们大量产生靶向细胞类型：甲状腺细胞，但同时该技术还能够用于其它临床相关细胞类型的研究，比如肺部细胞、产生胰岛素的细胞以及肝脏细胞等；研究人员希望本文研究能够帮助开发治疗性或基于干细胞的工程化技术来改善甲状腺及其它疾病患者的生活质量和健康状况。

原始出处：

Keri Dame, Steven Cincotta, Alex H. Lang, Reeti M. Sanghrajka, Liye Zhang, Jinyoung Choi, Letty Kwok, Talitha Wilson, Maciej M. Kańduła, Stefano Monti, Anthony N. Hollenberg, Pankaj Mehta, Darrell N. Kotton, Laertis Ikonomou.Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1.doi:10.1016/j.stemcr.2016.12.024

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2017-10-09 zhaozhouchifen

#Cell#

63 0
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2017-12-21 维他命

#CEL#

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2017-03-18 hb2008ye

#stem cell#

67 0
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2017-07-06 1341f33631m

什么时候可以临床……

106 0
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2017-08-19 yangjxjc

#甲状腺细胞#

66 0
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2017-03-23 1771e93b68m

太好了！希望早日上临床，现在甲状腺病人们实在是太多了…谢谢伟大的科学家们！你们辛苦了！

91 0
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2017-02-09 虈亣靌

嗯，学习了新的内容

82 0
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2017-02-07 ylzr123

好文，值得点赞，值得拥有，值得收藏！

121 0
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2017-02-06 wmu姿

突破性成果，以后有望应用到转化医学上

87 0
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topicList=[TopicDto(id=83705, encryptionId=6fcc83e0554, topicName=胚胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Sun Feb 05 23:44:00 CST 2017, time=2017-02-05, status=1, ipAttribution=)]
2017-02-05 ailian1202

#胚胎#

66 0

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Stem Cell Rep：科学家成功将胚胎干细胞转化成为甲状腺细胞

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