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日本用ES细胞制成“精子干细胞”:或解不孕难题

2016-12-11 佚名 中国新闻网

日本京都大学教授斋藤通纪的研究小组在6日的美国科学杂志网络版上发表一项成果:首次在老鼠试验中,由能够成为各种细胞或组织的“胚胎干细胞”(ES细胞)成功在体外制作出了成为精子基础的“精子干细胞”。报道称,研究小组还确认从该“精子干细胞”产生了精子。据悉,该成果有助于弄清精子的形成机理,促进探明造成不孕的原因。据悉,研究小组此前由老鼠的ES细胞成功在体外制作了成为精子和卵子基础的“原始生殖细胞”,但未


日本京都大学教授斋藤通纪的研究小组在6日的美国科学杂志网络版上发表一项成果:首次在老鼠试验中,由能够成为各种细胞或组织的“胚胎干细胞”(ES细胞)成功在体外制作出了成为精子基础的“精子干细胞”。

报道称,研究小组还确认从该“精子干细胞”产生了精子。据悉,该成果有助于弄清精子的形成机理,促进探明造成不孕的原因。

据悉,研究小组此前由老鼠的ES细胞成功在体外制作了成为精子和卵子基础的“原始生殖细胞”,但未能把原始生殖细胞进一步变为精子干细胞。

此次,研究小组把ES细胞制成的原始生殖细胞和雄鼠胎儿体细胞收集起来,在体外制作了人造精巢,然后成功把原始生殖细胞变成了精子干细胞。

在令其不持有生殖细胞的成年鼠的精巢中,放入上述精子干细胞后,产生了精子。将精子与卵子受精后,诞生了健康的老鼠。

虽然也有一部分没有成为精子,但研究小组探明了原因是基因甲基化(methylation)这一化学反应。

斋藤表示:“该研究有可能为治疗不孕和基因异常导致的疾病作出贡献。”

原始出处


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    2017-09-30 仁医06
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  3. [GetPortalCommentsPageByObjectIdResponse(id=1947954, encodeId=ef4f194e954cd, content=<a href='/topic/show?id=314fe04511' target=_blank style='color:#2F92EE;'>#ES细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7045, encryptionId=314fe04511, topicName=ES细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Sep 30 03:47:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294286, encodeId=7a0f129428641, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Tue Dec 13 01:47:00 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=161972, encodeId=55bd1619e2e2, content=棒棒哒???, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Sun Dec 11 12:28:55 CST 2016, time=2016-12-11, status=1, ipAttribution=)]
    2016-12-11 1e184d7bm65(暂无匿称)

    棒棒哒???

    0

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