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盘点:7月第4期BMJ研究精选

2017-07-28 zhangfan MedSci原创

BMJ

7月第4期BMJ研究精选


【1】心悸:动态心电图监测及循环记录仪的作用


Charbel Abi Khalil医生分享了一个病例:上周,一名62岁的男性患者主诉发生了4次心悸,他感到自己的心跳加快,气喘吁吁。但心悸症状和持续时间不同,2次是发生在酒后。询问得知患者无胸痛或晕厥,服用氨氯地平治疗高血压,经检查发现,患者血压为160/90mmHg;心率为82次/分,心音呼吸检查结果正常。

对于心悸患者,临床医生应注意患者症状类型和严重程度,心悸时机和医疗状况并重点询问患者以下情况:

1、频率和规律-持续数秒和随机发生的心悸常常是由于早搏引发的;房颤通常表现为快速和不规则的心悸;

2、伴随症状-询问是否出现头晕或意识丧失,上述症状常见于心脏结构异常患者发生特发性室性心动过速;

3、环境或诱发因素-询问患者是否进行了剧烈运动或摄入了如咖啡因、酒精或可卡因等物质,运动可诱发室上性心律失常。

患者、家属以及临床医生需要了解:

1、心悸十分常见,但超过1/2的心悸是有害的 (例如期前收缩);

2、应采取身体检查、12导联心电图以及血检等方法评估心悸症状的频率和严重程度;

3、若心悸患者存在心电图确诊的心律失常或传导障碍、以往心脏病史以及心悸伴随胸痛,晕厥或头晕等症状应及时到心脏专科就诊;

4、若患者静息心电图正常且对症状的持续时间和频率产生适应性后,应进行动态心电图监测。

【2】炎性关节炎的诊断与早期治疗


关节炎是最常见的自身免疫性疾病,每100000成人中,炎症性关节炎患者约80-100人。类风湿关节炎是最常见的炎症性关节炎,英国大约有500000名患者,包括脊柱关节病、银屑病关节炎、反应性关节炎、强直性脊柱炎。炎症性关节炎主要影响适龄工作人口,约有40%的类风湿关节炎患者无法正常工作。

系统的随机对照试验表明,炎症性关节炎早期治疗可以有效控制缓解症状,减少不可修复的损坏并降低其他疾病的发病率和死亡率。英国国家健康与护理研究所的指导方针和质量标准建议应对类风湿性关节炎进行早期积极治疗。Joanna Ledingham等对炎性关节炎的诊断和早期治疗建议如下:

1、急性或亚急性炎症性关节炎的症状包括:关节疼痛、早期晨僵和软组织肿胀;

2、早期诊断并使用症状缓解抗风湿药物 (DMARDS)以及皮质甾类激素有助于缓解症状并提高身体功能和影像学结果;

3、发作期患者应及时就诊;

4、在沟通顺畅的前提下,患者可自行进行处方和药物监测;

5、必需在医生指导下进行DMARDs或类固醇治疗方法的改变。

【3】小儿肺炎诊断进展


肺炎仍然是全球儿童死亡的主要原因之一。准确的诊断和归因、实施适当的预防或治疗策略可有效降低肺炎的危害。Heather J Zar等对近年来放射技术、标本采集和实验室诊断方法进展进行总结:胸部超声和胸部磁共振成像是新颖的放射诊断方法,但其临床应用仍需要实践的检验;快速、灵敏、多重上呼吸道标本检验或诱导痰法可以有效的检出引发肺炎的病原体,但这些方法难以确定疾病的因果关系;现有的宿主生物标志物难以区分细菌、混合细菌或病毒感染,新生物标志物的研究尚待确证。研究人员认为需要进行适当的人群基础的前瞻性研究,包括临床影响研究,以提高临床医生对病原体测试作用的理解。虽然肺炎影像学检查和实验室检测取得了一些突破,但肺炎诊断以及归因现状仍不理想。

【4】NICE公布最新的帕金森治疗指南


帕金森病是最常见的神经系统疾病之一,英国的发病率为每100000人250名患者。帕金森病运动症状包括经典的运动迟缓,静止性震颤,强直,姿势不稳;非运动症状包括抑郁、认知障碍和自主神经功能障碍。近日NICE对成人帕金森诊断以及治疗指南进行了升级,包括最新临床研究结果总结以及对2006年指南标准的替换,该指南反映了疾病治疗的一些新领域,例如冲动控制障碍以及疾病晚期症状缓解方法等。指南中帕金森病的诊断方法、与帕金森病患者沟通、药物神经保护治疗和帕金森病专科干预措施方法等方面没有变化。

本次NICE指南中相关专业人员以及家属需要了解:

1、冲动控制障碍可发生在帕金森病患者接受多巴胺治疗后的任何阶段;

2、帕金森病非运动症状的范围十分广泛,其控制方法包括抗帕金森病药物以及适合的非药物治疗;

3、帕金森症患者的治疗护理人员应当接受专业训练,提供专业的物理治疗、特定治疗、言语和语言治疗和认知行为治疗。

【5】电子烟有助于提高戒烟率以及戒烟成功率


Shu-Hong Zhu等考察了电子香烟与总体戒烟率的关系。研究人员分别对2001-02年, 2003年, 2006-07年, 2010-11年以及2014-15年吸烟人口统计学资料进行分析。主要终点是尝试戒烟率与成功戒烟率。161054名2014-15年间受访者中,38.2%的正在吸烟以及49.3%戒烟失败者使用过电子烟,使用电子烟可增加戒烟率65.1% vs 40.1%以及戒烟成功率8.2% vs 4.8%。2014-15年总人口戒烟率显著高于2010-11年5.6% v 4.5%,并高于其他统计年份 (戒烟率变化范围 4.3-4.5%)。

【6】英国贫富差距导致的健康差距


英国政府1997-2010年间实施了健康不平等应对策略,旨在消除英国各阶层之间的健康不平等情况。近日Ben Barr等对该政策实施后社会弱势群体的健康情况进行了考察。研究人员对3个时间段:政策实施前1983-2003、实施中2004-12以及实施后2013-15,英国贫困地区与其他地区人口寿命差异进行了分析。在政策实施前,贫困地区与英国其他地区,人口寿命差距为:男性0.57个月/年,女性0.3个月/年;政策实施中,人口寿命差距为:男性0.91个月/年,女性0.50个月/年;政策实施后期人口寿命差距为:男性0.68个月/年,女性0.31个月/年。至2012年,不发达地区男性人口寿命差缩短1.2年,女性缩短0.6年。研究认为,相关政策影响了不发达地区人口的平均寿命,缩短了贫富差距导致的寿命差异。但政策结束后健康不平等重新出现,这一现象应引起政府的高度关注。

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    2018-06-18 gaoxiaoe
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    2017-08-04 hfuym10906

    学习了学习了学习了学习了

    0

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    2017-07-29 130****4638

    学习了受益匪浅

    0

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    2017-07-29 jihuaijun1112

    学习学习学习

    0

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    2017-07-28 有备才能无患

    房颤通常表现为快速和不规则的心悸;心悸十分常见,但超过1/2的心悸是有害的(例如期前收缩);

    0

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    2017-07-28 1e1fb5b0m85(暂无匿称)

    没看原文,但只看简介,第一篇文章的创新点何在…?这些结论,感觉无法引起看的欲望。。

    0

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    2017-07-28 damiao93

    学习了,谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1848362, encodeId=724f1848362a6, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon Jun 18 19:23:00 CST 2018, time=2018-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229847, encodeId=501c22984e2e, content=学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Fri Aug 04 07:02:20 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227582, encodeId=799d22e58240, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Jul 29 08:20:39 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227428, encodeId=147e22e42847, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Jul 29 00:11:57 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227346, encodeId=bc7622e3466d, content=房颤通常表现为快速和不规则的心悸;心悸十分常见,但超过1/2的心悸是有害的(例如期前收缩);, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Jul 28 21:13:07 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227339, encodeId=822822e339e5, content=没看原文,但只看简介,第一篇文章的创新点何在…?这些结论,感觉无法引起看的欲望。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=39c22014861, createdName=1e1fb5b0m85(暂无匿称), createdTime=Fri Jul 28 21:04:25 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227337, encodeId=f9e022e33713, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCkPCv9CVFBmWOibyBArQwSeQLxvxz9OaumlaSUZjfCWTxbXduhuG2xCJUPs1nB9nd4gxZknH7IZj/0, createdBy=52281985209, createdName=damiao93, createdTime=Fri Jul 28 21:02:33 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227315, encodeId=68af22e315ec, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Jul 28 19:42:29 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227279, encodeId=341722e279be, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Fri Jul 28 16:52:25 CST 2017, time=2017-07-28, status=1, ipAttribution=)]
    2017-07-28 1dd8c52fm63(暂无匿称)

    了解了解

    0

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    2017-07-28 尹玉伟

    厉害厉害……学习了

    0

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