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Nat Commun：靶向介导MG53蛋白质有助于急性肺损伤的修复

2014-07-29 佚名 生物谷

肺部细胞损伤蛋白质疗法
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近日，来自俄亥俄州立大学医学中心的研究人员利用名为MG53的蛋白质成功治愈了急性和慢性的肺部细胞损伤，而该蛋白质也被证明可以有效抑制肺部细胞损伤，相关研究成果刊登于国际杂志Nature Communications上。 研究者Jianjie Ma表示，最新研究显示，MG53在肺部组织中表达，这一点或许可以被用于修复许多类型的肺部损伤；当机体血液供给重新回归到缺氧状态下时，缺失MG53的对照动

近日，来自俄亥俄州立大学医学中心的研究人员利用名为MG53的蛋白质成功治愈了急性和慢性的肺部细胞损伤，而该蛋白质也被证明可以有效抑制肺部细胞损伤，相关研究成果刊登于国际杂志Nature Communications上。

研究者Jianjie Ma表示，最新研究显示，MG53在肺部组织中表达，这一点或许可以被用于修复许多类型的肺部损伤；当机体血液供给重新回归到缺氧状态下时，缺失MG53的对照动物就会对因再氧合而引发的损伤更加敏感。在用重组MG53（rhMG53）的蛋白质治疗动物后研究者发现，动物机体的肺部细胞可以明显免于损伤破坏。目前治疗肺部损伤的疗法包括静脉注射药物或者吸入式治疗，蛋白质运输疗法的使用则可以降低急性肺部损伤以及慢性气肿的症状。

如果rhMG53疗法在人类机体中同样可以发挥作用，那么利用此疗法给患者带来的益处将变得非常明显；如果该疗法可以抑制并且修复心脏和肺部细胞损伤，那么其或许可以在患者进行手术之前来应用于患者机体中以预防机体的损伤并且修复伤口。

最后，研究者Peter Mohler教授说道，这项研究是转化医学研究领域的一项非常好的模板研究，对于临床医生和研究者们来说非常关键，而且研究结果也为奠定新的细胞生物学发现，以及开发治疗肺部损伤患者的新型疗法提供了新的研究思路和研究依据。

原始出处：

Jia Y1, Chen K2, Lin P3, Lieber G4, Nishi M5, Yan R6, Wang Z7, Yao Y7, Li Y7, Whitson BA8, Duann P8, Li H8, Zhou X8, Zhu H9, Takeshima H5, Hunter JC4, McLeod RL4, Weisleder N10, Zeng C7, Ma J11.Treatment of acute lung injury by targeting MG53-mediated cell membrane repair.Nat Commun. 2014 Jul 18;5:4387. doi: 10.1038/ncomms5387.

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    2015-06-23 liye789132251

    #Nat#

    0

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    2015-01-09 liuli5079

    #COMMUN#

    0

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    2015-06-23 柳叶一刀

    #白质#

    0

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    2014-07-31 cmj8wellington

    #蛋白质#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1880203, encodeId=b9fc18802033d, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 23 06:16:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086721, encodeId=28862086e21ef, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Jan 09 19:16:00 CST 2015, time=2015-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765528, encodeId=eaef1e6552812, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Jun 23 01:16:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296891, encodeId=564c12968917b, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395391, encodeId=329313953915d, content=<a href='/topic/show?id=d051523897d' target=_blank style='color:#2F92EE;'>#急性肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52389, encryptionId=d051523897d, topicName=急性肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/B41263AF328B0A74CD1BA5216160E938/100, createdBy=20992500196, createdName=ms6323715314570549, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396854, encodeId=d7711396854df, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503294, encodeId=57811503294c0, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=)]
    2014-07-31 ms6323715314570549

    #急性肺损伤#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1880203, encodeId=b9fc18802033d, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 23 06:16:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086721, encodeId=28862086e21ef, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Jan 09 19:16:00 CST 2015, time=2015-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765528, encodeId=eaef1e6552812, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Jun 23 01:16:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296891, encodeId=564c12968917b, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395391, encodeId=329313953915d, content=<a href='/topic/show?id=d051523897d' target=_blank style='color:#2F92EE;'>#急性肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52389, encryptionId=d051523897d, topicName=急性肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/B41263AF328B0A74CD1BA5216160E938/100, createdBy=20992500196, createdName=ms6323715314570549, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396854, encodeId=d7711396854df, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503294, encodeId=57811503294c0, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=)]
    2014-07-31 智者为医08

    #损伤#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1880203, encodeId=b9fc18802033d, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 23 06:16:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086721, encodeId=28862086e21ef, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Jan 09 19:16:00 CST 2015, time=2015-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765528, encodeId=eaef1e6552812, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Jun 23 01:16:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296891, encodeId=564c12968917b, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395391, encodeId=329313953915d, content=<a href='/topic/show?id=d051523897d' target=_blank style='color:#2F92EE;'>#急性肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52389, encryptionId=d051523897d, topicName=急性肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/B41263AF328B0A74CD1BA5216160E938/100, createdBy=20992500196, createdName=ms6323715314570549, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396854, encodeId=d7711396854df, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503294, encodeId=57811503294c0, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Thu Jul 31 00:16:00 CST 2014, time=2014-07-31, status=1, ipAttribution=)]
    2014-07-31 tastas

    #肺损伤#

    0

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