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J Am Acad Child Psy:儿童精神障碍是否会增加物质依赖性疾病?

2017-05-13 tianxuexin MedSci原创

使用荟萃分析评估儿童期精神障碍(即注意力缺陷/多动障碍[ADHD],对抗性障碍/行为障碍[ODD / CD],焦虑障碍和抑郁症)发生药物性相关疾病的潜在风险。

使用荟萃分析评估儿童期精神障碍(即注意力缺陷/多动障碍[ADHD],对抗性障碍/行为障碍[ODD / CD],焦虑障碍和抑郁症)发生药物性相关疾病的潜在风险。

研究人员通过检索PubMed,Embase和PsycInfo等相关数据库的英文期刊相关纵向研究资料的同行评议,筛选1986年至2016年5月期间儿童期(<18岁)ADHD,ODD / CD,焦虑或抑郁症与晚期酒精,尼古丁或其他药物相关疾病或物质使用障碍的关系,。两名研究人员进行了所有审查阶段。进行了遵循流行病学观察研究(MOOSE)的Meta分析。

研究人员对762187名参与者进行37项定量分析研究。这些研究包括22029名ADHD患者,434名ODD / CDD患者,1433名焦虑症患者和2451名抑郁患者。总共提取了97个ESs用于分析。 Meta分析显示ADHD患者的成瘾风险显着增加(n = 23,优势比 = 2.27,95%CI = 1.98-3.67;酒精优势比= 2.15,95%CI = 1.56-2.97,药物优势比= 1.52,95% CI = 1.52-5.27,尼古丁优势比= 2.52,95%CI = 2.01-3.15,SUD优势比 = 2.61,95%CI = 1.77-3.84),ODD / CD的成瘾风险也明显增加(n = 8,优势比 = 3.18,95%CI = 1.97 -5.80;酒精优势比= 1.73,95%CI = 1.51-2.00,药物优势比= 4.24,95%CI = 1.3.21.5.59,尼古丁优势比= 4.22,95%CI = 3.21-5.55,SUD优势比 = 4.86, 95%CI = 3.09-7.56)以及焦虑症也是如此(n = 13,优势比 = 2.03,95%CI = 1.47-2.81;即酒精= 1.10,95%CI = 1.02-1.19,尼古丁优势比= 2.56,95%CI = 1.89-3.48,SUD优势比 = 2.20,95%CI = 1.41-3.43),但不适用于焦虑症(n = 15,优势比 = 1.34,95%CI = .90-1.55,ns)。

研究结论显示,不仅儿童ADHD增加了发生物质相关疾病的风险,而且儿童期ODD / CD和抑郁症也增加了这种物质相关性疾病的风险。焦虑症似乎并没有增加未来与物质有关的疾病的风险,尽管研究结果是高度异质性的。这些发现强调需要早期检测和干预以预防后期生活中发生物质相关性的疾病。

原始出处:

Annabeth P. Groenman, et al. Childhood Psychiatric Disorders as Risk Factor for Subsequent Substance Abuse: A Meta-Analysis. Journal of the American Academy of Child & Adolescent Psychiatry.Available online 11 May 2017.https://doi.org/10.1016/j.jaac.2017.05.004

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    2017-07-04 lishizhe
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    2018-03-31 docwu2019
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    2017-05-13 1e0f8808m18(暂无匿称)

    儿童精神障碍增加物质依赖性疾病

    0

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    2017-05-13 明月清辉

    谢谢分享,学习了

    0

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