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Heart:英国先天性心脏病患者的心脏或心肺移植

2019-01-13 xiangting MedSci原创

虽然预计CHD患者的移植会增多,但英国的实际数字似乎滞后于晚期心衰CHD患者的增多。

先天性心脏病(CHD)患者的寿命延长与晚期并发症相关,主要是心衰,这使得患者可能不适合重新手术并且药物治疗无效,因此转诊进行移植。这项研究评估了英国CHD患者心脏和心肺移植的当前作用和未来前景。

对英国1997-2015年的医院事件进行了回顾性分析,确定接受心脏或心肺移植的CHD患者(ICD-10'Q2xx.x')。

共有444例患者进行了469次移植(82.2%为心脏移植和17.8%为心肺移植)。一半移植患者的CHD复杂性为轻或中度,该百分比随时间而增加(p=0.001)。总体而言,随着时间移植越来越多,心肺移植的比例下降(p<0.0001),而成人移植比例保持不变。第1年的死亡率较高,尤其是心肺移植后,但此后死亡率仍然相对较低。老年人和心肺移植是死亡的强预测因子。虽然预计CHD患者的移植会增多,但英国的实际数字似乎滞后于晚期心衰CHD患者的增多。

目前和未来预测的CHD移植数量增多似乎与CHD人群的扩张并不匹配,尤其是在成人中。应进一步投资和改变政策以增加供体数量,增加CHD移植能力,以应对潜在CHD受者的增多,并优化这一不断增长人群的移植结局。

原始出处:

Konstantinos Dimopoulos. Heart or heart-lung transplantation for patients with congenital heart disease in England. Heart. 12 January 2019.

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    2019-01-15 zhaojie88
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    2019-01-15 huirong
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    2019-01-15 slcumt

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