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Gastroenterology:慢性肝病肝外并发症死亡趋势研究——2007-2017

2019-10-03 MedSci MedSci原创

HCV抗病毒药物的使用大幅降低了HCV感染人群的肝相关死亡风险

慢性肝病肝外并发症的死亡率趋势近年来发生了很大的变化。近日研究人员就美国病毒性肝炎、酒精性肝病(ALD)和非酒精性脂肪肝引起的肝外并发症的死亡率趋势进行了考察。

2007-2017年,研究人员利用美国人口普查和国家卫生统计中心的死亡率记录进行这项基于人口的研究。

研究发现,2007-13年间,丙型肝炎病毒(HCV)感染患者的肝相关死亡率持续上升,但2014-17年间,由于直接作用抗病毒药物(DAA)的使用,死亡率下降。在HCV感染患者中,肝外癌症的年龄标准化死亡率为2.6%,心血管疾病死亡率为1.9%,糖尿病为3.3%。2007-17年间,HBV感染者,肝相关死亡率稳定下降,乙型肝炎病毒引起的肝外并发症的年龄标准化死亡率平均每年增加2.0%。虽然ALD与肝脏相关的死亡率持续上升,但肝外并发症的死亡率并没有明显的变化。在非酒精性脂肪肝患者中,最常见的死因是心血管疾病,随着研究时间的推移,心血管疾病逐渐增加,而肝脏相关死亡率迅速上升。

研究发现,HCV抗病毒药物的使用大幅降低了HCV感染人群的肝相关死亡风险。

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    2020-02-22 丁鹏鹏
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    2019-10-09 许安
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