2015新版《美国慢性HBV感染治疗流程》公布

2015-07-23 国际肝病国际肝病

2015年7月15日，Clin Gastroenterol Hepatol在线发表了新版《美国慢性HBV感染治疗流程》。负责该治疗流程修订的美国肝病专家小组组长、迈阿密大学医学院Martin教授介绍道：“目前，慢性乙型肝炎(CHB)仍然是在包括美国的全世界范围内的一个重要的公共卫生问题。2004年，美国肝病专家小组于制定了首个用于CHB管理的治疗流程，随后在2006年和2008年分别进行了更新。自

2015年7月15日，Clin Gastroenterol Hepatol在线发表了新版《美国慢性HBV感染治疗流程》。负责该治疗流程修订的美国肝病专家小组组长、迈阿密大学医学院Martin教授介绍道：“目前，慢性乙型肝炎(CHB)仍然是在包括美国的全世界范围内的一个重要的公共卫生问题。2004年，美国肝病专家小组于制定了首个用于CHB管理的治疗流程，随后在2006年和2008年分别进行了更新。自从2008年后，随着关于已批准药物的长期疗效及安全性的临床研究大量增加，我们对于CHB的治疗选择更加明确。因此，对于该治疗流程的更新非常有必要。新版治疗流程主要是基于科学文献提供的临床证据，同时也体现了专家组的临床经验和共识。”

证据表明，强效抗病毒药物可消退广泛性肝纤维化甚至肝硬化，从而可能改变CHB的自然史，并且可以将耐药风险降至最低。

新版治疗流程对于CHB抗病毒治疗的主要目标及治疗意见如下：持续抑制血清HBV DNA至很低或检测不出的水平。对于血清HBV DNA >2000 IU/mL、丙氨酸氨基转移酶(ALT)升高以及已经发生任何程度肝纤维化的CHB患者，无论他们的HBeAg状态，均应进行抗病毒治疗;对于血清HBV DNA >2000 IU/mL以及ALT升高、尚无肝纤维化证据的CHB患者，也可以考虑抗病毒治疗。

在用药选择方面，新版治疗流程指出首选一线治疗药物包括聚乙二醇干扰素α-2a、恩替卡韦和替诺福韦酯。在确定治疗选择时，需要考虑的因素包括疗效、安全性、耐药率、应用方法、疗程和花费等。

原始出处：

Martin P, Lau DT, Nguyen MH, et al. A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2015 Update. Clin Gastroenterol Hepatol. 2015 Jul 15.

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#插入话题

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2015-12-26 忠诚向上

新的知识

129 0
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2015-11-08 xjbtdbs150wgf

基于我国的新药明显延迟，在国内的应用需要适当修改。

167 0
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2016-05-24 klivis

#HBV#

54 0
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2015-08-15 lecoo

对于国人的治疗估计还得多改改

166 0
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2015-08-05 hlycom3356

是最新的研究进展

170 0
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2015-08-05 hlycom3356

这些药物很有效

135 0
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2015-07-25 Tommy1951

#HBV感染#

63 0

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