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Heart:女性生殖因素与心血管疾病相关性分析!

2018-01-16 xing.T MedSci原创

由此可见,初潮较早、绝经较早、首次生产年龄较早、有流产、死胎或子宫切除史,均与晚年CVD风险增高有关。子女数量与CVD事件之间的关系在男性和女性之间是相似的。

研究表明女性生殖因素与心血管疾病(CVD)的风险有关;然而,调查结果并不统一。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员评估了女性生殖因素与CVD事件之间的相关性。

在2006年至2010年间,英国生物数据库招募了超过50万年龄在40-69岁的参与者。在7年的随访期间,研究人员在基线时没有心血管病史的265440名女性215088名男性金额共记录到了9054例CVD患者(34%为女性),5782例冠心病(CHD)患者(28%为女性)和3489例卒中患者(43%为女性)。研究人员采用Cox回归模型得到了生殖因素与CVD、CHD和卒中之间相关性的校正后风险比(HR)。

对于CVD,较早的初潮(<12岁)调整后的风险比(95%可信区间)为1.10(1.01-1.30),首次生产年龄每增加一年的风险比为0.97(0.96-0.98),每次流产的风险比1.04(1.00-1.09),每死产的风险比为1.14(1.02-1.28),更年期较早(<47岁)的风险比为1.33(1.19-1.49)。未行卵巢切除术或先前卵巢切除术后子宫切除术患者发生CVD的调整后风险比分别为1.16(1.06-1.28)和2.30(1.20-4.43)。对于女性和男性每个额外增加一个孩子与CVD相关的风险比分别为1.03(1.00-1.06)和1.03(1.02-1.05)。

由此可见,初潮较早、绝经较早、首次生产年龄较早、有流产、死胎或子宫切除史,均与晚年CVD风险增高有关。子女数量与CVD事件之间的关系在男性和女性之间是相似的。

原始出处:

Sanne AE Peters,et al.Women’s reproductive factors and incident cardiovascular disease in the UK Biobank.Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2017-312289

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    2018-01-18 zhaojie88
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createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jan 18 06:34:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279149, encodeId=18de2e914944, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Tue Jan 16 19:36:27 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279104, encodeId=eb4d2e91047a, content=研究表明女性生殖因素与心血管疾病(CVD)的风险有关,然而.调查结果并不统一.近日.心脏病领域权威杂志Heart上发表了一篇研究文章.研究人员评估了女性生殖因素与CVD事件之间的相关性., beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Jan 16 16:41:23 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-18 slcumt
  8. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/vLodSSFTQLpHtfwJicWJibSWH7pbiauxvpCMvQIv0N9Oes8vHkDkCIW2HNDkt7icUq3RCZiaDcHR9Rap17fFySRbiaFg/132, createdBy=9f202500205, createdName=ms3297076796458174, createdTime=Fri Oct 12 07:34:00 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356644, encodeId=0224135664494, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jan 18 06:34:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498354, encodeId=f3741498354f7, content=<a href='/topic/show?id=bb6f89e145a' target=_blank 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createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jan 18 06:34:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279149, encodeId=18de2e914944, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Tue Jan 16 19:36:27 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279104, encodeId=eb4d2e91047a, content=研究表明女性生殖因素与心血管疾病(CVD)的风险有关,然而.调查结果并不统一.近日.心脏病领域权威杂志Heart上发表了一篇研究文章.研究人员评估了女性生殖因素与CVD事件之间的相关性., beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Jan 16 16:41:23 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-16 hhh678

    henhao

    0

  9. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Jan 16 16:41:23 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-16 有备才能无患

    研究表明女性生殖因素与心血管疾病(CVD)的风险有关,然而.调查结果并不统一.近日.心脏病领域权威杂志Heart上发表了一篇研究文章.研究人员评估了女性生殖因素与CVD事件之间的相关性.

    0

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